ArticleScience advances2026
Three-dimensional aperture-driven photoacoustic tomography (3D-ADPAT).
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
14 authors.
Funding
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Abstract
As a powerful modality for biomedical research, photoacoustic computed tomography (PACT) offers the combination of optical specificity and acoustic penetration for in vivo visualization. However, its performance is limited by a trade-off between ultrasound detection aperture and sensitivity, compromising image contrast, resolution, and penetration depth. Here, we introduce three-dimensional aperture-driven photoacoustic tomography (3D-ADPAT) to overcome these limitations, synergistically combining a high-numerical-aperture focused ultrasonic transducer (HNA-FUT) with a phase-inverted focusing-equivalent reconstruction (PIFER) algorithm. This approach yields ~2.21-fold enhancement in spatial resolution and ~10-fold increase in contrast-to-noise ratio. 3D-ADPAT's performance was validated through comprehensive simulations and phantom studies and further confirmed by in vivo whole-body imaging that resolved deep-seated anatomies and tracked small-molecule metabolic pathways. Furthermore, a barrel-shaped array-based 3D-ADPAT implementation was designed, supporting dynamic imaging within a large field of view or across variable spatiotemporal scales. In summary, 3D-ADPAT provides a powerful tool for advanced photoacoustic systems, promising to accelerate frontier biomedical research.
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