Evidence map›Paper›PMID 42361174›Full record

ArticleScience advances2026

Wireless knee joint monitoring using biodegradable single-ended pressure sensor in osteoarthritis management.

Jinyoung Park, Nidhi Sharma, Aseno Sakhrie, Yuhui Zhu, Gulsah Erel-Akbaba, Nitu Bhaskar, Zhiming Li, Somasundaram Prasadh, Parbeen Singh, Feifei Huang and 9 more

Abstract read
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Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jinyoung ParkDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-0943-3649
Nidhi SharmaDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-6999-2461
Aseno SakhriePolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-1847-8518
Yuhui ZhuPolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.ORCID 0009-0001-2150-983X
Gulsah Erel-AkbabaPolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-3287-5277
Nitu BhaskarCenter for Clean Energy Engineering, University of Connecticut, Storrs, CT 06269, USA.
Zhiming LiDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-2367-2136
Somasundaram PrasadhCenter for Clean Energy Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-2615-393X
Parbeen SinghPolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0001-7858-8973
Feifei HuangDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Cao-Sang TruongDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-2354-5743
Kishan AngadiDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Achal DuhoonDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-5595-7016
Thinh T LeDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Tra VinikoorDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-7637-6296
Dong ChenDepartment of Pathology and Laboratory Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.ORCID 0000-0001-6661-9410
Bonnie PlickertAnimal Care Services, University of Connecticut, Storrs, CT 06269, USA.
Ramaswamy M ChidambaramAnimal Care Services, University of Connecticut, Storrs, CT 06269, USA.
Thanh D NguyenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-0813-4807

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee joint loading regulates cartilage regeneration and degeneration, influencing both healing and osteoarthritis (OA) progression. Although defining the optimal range of loading is essential, in vivo measurement remains challenging because current nonbiodegradable sensors require removal surgeries, and computational models provide only indirect estimates. Here, we report a fully biodegradable, implantable piezoelectric pressure sensor composed of biocompatible materials and designed with a single-ended configuration, consisting of only one electrode. This configuration maintained stable performance for more than 2 months, which, to our knowledge, is among the longest functional lifetimes reported for biodegradable pressure sensors. Ex vivo studies simulating the in vivo environment demonstrated accurate monitoring of intracranial pressure and knee movement, while in vivo implantation in a rabbit model confirmed both robust biocompatibility and reliable monitoring of joint loading during natural activities. This platform could enable feedback-guided, personalized rehabilitation regimes for OA management by identifying optimal joint loading conditions.

Indexed as

Absorbable ImplantsKnee JointOsteoarthritisOsteoarthritis, KneeWireless TechnologyAnimalsHumansMonitoring, PhysiologicPressureRabbits

Identifiers

PMID42361174
PMCPMC13308608

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.