Evidence map›Paper›PMID 42361166›Full record

ArticleScience advances2026

A subunit vaccine for multiple respiratory viruses.

Qinzhe Li, Wei-Chiao Huang, Sara H Mahmoud, Chengjin Ye, Zachary R Sia, Yiting Song, Yang Jiao, Yuan Luo, Shiqi Zhou, Reuben M Pul and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Qinzhe LiDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.ORCID 0009-0004-0455-3830
Wei-Chiao HuangDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.ORCID 0000-0001-6239-3266
Sara H MahmoudHost-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX 78227 USA.ORCID 0000-0002-1011-5608
Chengjin YeHost-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX 78227 USA.ORCID 0000-0002-1934-9494
Zachary R SiaDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.ORCID 0009-0004-4013-2531
Yiting SongDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Yang JiaoDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Yuan LuoDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Shiqi ZhouDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Reuben M PulDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.
Hilliard L KutscherPOP Biotechnologies, Buffalo, NY 14228 USA.ORCID 0000-0003-4779-2132
Wen-Ling HsuDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.ORCID 0000-0002-0707-6863
Dominic ArpinDepartment of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0009-0001-3567-7922
Joaquin OrtegaDepartment of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0002-9423-3344
Luis Martinez-SobridoHost-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX 78227 USA.ORCID 0000-0001-7084-0804
Bruce A DavidsonDepartment of Anesthesiology, State University of New York at Buffalo, Buffalo, NY 14203, USA.ORCID 0000-0001-8223-1870
Jonathan F LovellDepartment of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY 14260, USA.ORCID 0000-0002-9052-884X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seasonal influenza viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and respiratory syncytial virus (RSV) drive substantial mortality worldwide. Vaccines against these respiratory viruses are traditionally administered separately, and, while some emerging technologies have shown promise to address multiple pathogens simultaneously, subunit protein vaccines have lagged behind. Here, we describe a nanoliposome-based vaccine platform that codisplays recombinant hemagglutinin ectodomains from three seasonal influenza strains, the SARS-CoV-2 receptor binding domain, and the RSV F ectodomain, in prefusion form. In mouse, ferret, and cotton rat models, immunization elicited protective immunity against the three major respiratory viruses, with antibody responses comparable to those induced by the corresponding monovalent formulations. These findings highlight the potential for multivalent recombinant protein vaccines delivered via nanoliposome carriers to provide immunologic protection against a broad spectrum of respiratory viruses.

Indexed as

Respiratory Syncytial Virus InfectionsAnimalsAntibodies, ViralFerretsHumansLiposomesMiceProtein Subunit VaccinesRespiratory Syncytial VirusesSARS-CoV-2SigmodontinaeVaccines, SubunitAntibodies, ViralLiposomesProtein Subunit VaccinesVaccines, Subunit

Identifiers

PMID42361166
PMCPMC13308616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.