ArticleScience advances2026
Unraveling the origin of the vertebrate kidney: Emergence from a somitic compartment.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Somite compartmentalization and kidney development are considered as two distinct developmental processes. It is widely acknowledged that in amniotes as well as in frogs and bony fish, the pronephros and therefore the adult kidney develop from the intermediate mesoderm. Our study sheds light on the evolution of pronephros formation in vertebrates, revealing its ancient origin from a specific, segmented, somitic subterritory, the nephrotome, which buds off during early development to create the nephric duct. In nonvertebrate chordates, mesoderm markers are expressed in common progenitor cells of dermomyotome and nephrotome, whereas in cyclostomes and elasmobranchs, they segregate into distinctive domains within the somite. Two main discoveries are thus described here: (i) The intermediate mesoderm originated developmentally and evolutionarily from a specific domain within somitic tissues, and (ii) the pronephric progenitor cell domain is redefined as the fifth somitic compartment, the nephrotome, alongside the dermatome, myotome, syndetome, and sclerotome. Our results support the hypothesis that this fifth somitic domain, the nephrotome, is the evolutionary predecessor of the intermediate mesoderm, giving rise to the pronephros and hence to the adult kidney.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.