Evidence map›Paper›PMID 42360778›Full record

ArticleRheumatology (Oxford, England)2026

Diagnostic approaches to Kawasaki disease worldwide: the results from the JIR-CliPS network.

Jurgita Marčiulynaitė, Daiva Gorczyca, Aušra Šnipaitienė, Konstantinos Pateras, Teresa Giani, Margarita Ganeva, Zeynep Balik, Francois Hofer, Marie Frank, Jaanika Ilisson and 10 more

Abstract read
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Article in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Jurgita MarčiulynaitėDepartment of Paediatrics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Daiva GorczycaDepartment of Paediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany.ORCID 0000-0002-5044-5513
Aušra ŠnipaitienėDepartment of Paediatrics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Konstantinos PaterasDepartment of Statistics, Athens University of Economics and Business, Athens, Greece.
Teresa GianiDepartment of Paediatrics, AOU Meyer IRCCS, Florence, Italy.ORCID 0000-0001-9292-7601
Margarita GanevaDepartment of Paediatric Rheumatology, Medical University Sofia, Sofia, Bulgaria.
Zeynep BalikDepartment of Paediatric Rheumatology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
Francois HoferFondation Rhumatismes-Enfants-Suisse, Lausanne, Switzerland.
Marie FrankFondation Rhumatismes-Enfants-Suisse, Lausanne, Switzerland.
Jaanika IlissonDepartment of General Paediatrics and Neurology, Tartu University Hospital, Children's Clinic, Tartu, Estonia.
Jacek PostepskiDepartment of Paediatric Pulmonology and Rheumatology, Medical University of Lublin, Lublin, Poland.
Judith Sánchez-ManubensPaediatric Rheumatology Unit, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Sabadell, Spain.
Arūnė RamanauskienėGijos Clinics, Kaunas, Lithuania.
Cristina Costa Duarte LannaLocomotor System Department, Rheumatology Unit, Universidade Federal of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Jacqueline YanDepartment of Paediatric Rheumatology, Starship Children's Health and University of Auckland, Auckland, New Zealand.
Dzifa DeyRheumatology Unit, Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana.ORCID 0000-0002-3339-5112
Seza OzenDepartment of Paediatric Rheumatology, Hacettepe University, Ankara, Turkey.ORCID 0000-0003-2883-7868
Michael HoferFondation Rhumatismes-Enfants-Suisse, Lausanne, Switzerland.
Yosef UzielDepartment of Paediatrics, Meir Medical Centre, Kfar Saba, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0003-4655-1652
Tilmann KallinichDepartment of Paediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany.

Funding

COST Action CA21168-Improving outcome of Juvenile Inflammatory RheumatismCOST (European Cooperation in Science and Technology)universally applicable clinical practice strategies (JIR-CliPS)
6 · The paper itself

Abstract

objectivesTo evaluate worldwide differences of diagnostic approaches to Kawasaki disease (KD), focusing on aspects, which vary throughout major international guidelines, including criteria for diagnostic and risk stratification.

methodsAn online English-language survey was distributed to physicians worldwide between June 2022 and November 2024 through the JIR-CliPS (juvenile inflammatory rheumatism; clinical practice strategies) network, aiming to collect real-life diagnostic and management practices in juvenile rheumatic conditions, including KD. Responses addressing the definitions of complete and incomplete KD and criteria identifying patients at high-risk for coronary artery lesions (CALs), were analysed. Descriptive statistics, comparisons of categorical variables, sensitivity and weighted analysis were performed.

resultsOne hundred and ninety-two physicians from 51 countries completed the survey. All respondents accepted ≥5 days of fever plus four criteria as diagnostic for complete KD. Thirty-two percent (n = 62/192, 95% CI [25.74, 39.40]) also accepted shorter fever duration, particularly physicians from France (n = 16/24, 63%, 95% CI [44.68, 84.37]). Ninety-four percent (n = 178/189, 95% CI [89.83, 97.06]) diagnosed incomplete KD based on fever and three clinical criteria. Forty-four percent (n = 84/189, 95% CI [37.23, 51.83]) accepted the presence of CALs as diagnostic in febrile patients, even without other clinical criteria; this approach was more common among Europeans. Infant age and elevated coronary Z-scores were identified as key indicators for coronary involvement. Years of experience did not influence the results.

conclusionDespite shared core diagnostic principles, country-specific differences persist in real-life clinical practice regarding fever duration, minimum clinical criteria and the role of coronary artery findings in diagnosing complete and incomplete KD. Future real-life studies are needed to support timely and consistent diagnosis.

Indexed as

Mucocutaneous Lymph Node SyndromePractice Patterns, Physicians'FemaleGlobal HealthHumansSurveys and Questionnairesclinical practicecoronary arterydiagnostic approachesKawasaki diseasesurveyworldwide

Identifiers

PMID42360778
PMCPMC13378453

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.