ArticleInternal and emergency medicine2026
Clinical characteristics, diagnosis and prognosis of statin-induced acute pancreatitis.
Article in Internal and emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo explore the clinical characteristics of statin-induced acute pancreatitis and provide a reference for safe clinical medication.
methodsCase reports/series of statin-induced acute pancreatitis were collected for retrospective analysis by searching Chinese and English databases up to May 31, 2025.
resultsA total of 34 patients were reported, with a median age of 59 years (range 36, 86). These statins involved simvastatin (35.3%), lovastatin (14.7%), pravastatin (17.6%), atorvastatin (14.7%), rosuvastatin (11.8%), and fluvastatin (5.8%). The onset time of acute pancreatitis ranged from 8 h to 10 years after administration, with a median time of 3.5 months. Acute pancreatitis can occur with statins ranging from low doses to high doses. Abdominal pain (67.6%), vomiting (38.2%) and nausea (29.4%) were the main clinical symptoms. Laboratory tests showed elevated levels of amylase and lipase, with median values of 742U/L (range 67, 3001) and 1730.5U/L (range 82, 5579), respectively. Triglyceride levels were normal, with a median value of 146.5 mg/dL (range 49, 317). White blood cells were elevated, with a median of 13.7 × 10
conclusionStatin-induced pancreatitis has a class effect that may be independent of duration or dosage. Clinicians should be aware of the possibility of statin-induced acute pancreatitis in order to facilitate early diagnosis and management.
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