ArticleIrish journal of medical science2026
Exertional leg pain is associated with ıncreased disease activity and musculoskeletal ınvolvement, but not MEFV genotype, in familial Mediterranean fever.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamilial Mediterranean fever (FMF) is characterized by recurrent inflammatory attacks and marked clinical heterogeneity. Exertional leg pain (ELP) is a common but underrecognized manifestation.
aimsWe aimed to evaluate the association of ELP with disease activity, inflammatory burden, and MEFV genotype distribution in patients with FMF.
methodsIn this retrospective cross-sectional study, FMF patients from a tertiary rheumatology center were stratified according to the presence of ELP. Demographic and clinical features, annual attack frequency, International Severity Scoring System for FMF (ISSF), colchicine dose, and inflammatory markers including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were recorded. MEFV genotype distributions were compared between groups.
resultsAmong 135 patients, 65 (48.1%) had ELP. Demographic characteristics were similar between groups, although smoking was more frequent in patients with ELP. Patients with ELP had less frequent serositis but more prominent musculoskeletal involvement, particularly arthritis and enthesitis. They also exhibited higher annual attack frequency, higher ISSF scores, and elevated ESR and CRP levels. MEFV genotype distribution did not differ between groups.
conclusionsELP is associated with higher disease activity, increased inflammatory burden, and a musculoskeletal-predominant phenotype in FMF, while no significant association with MEFV genotype distribution was observed in this cohort. Clinically, the presence of ELP may help identify patients with increased inflammatory burden who may benefit from closer assessment.
Indexed as
Identifiers
42360602What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.