Evidence map›Paper›PMID 42360509›Full record

ArticleAmino acids2026

Effects of taurine on skeletal muscle in senescence-accelerated mice and C2C12 myoblasts and myotubes.

Yiying Huang, Hatasu Kobayashi, Xiaoying Zhou, Keiya Matsuoka, Jun Kawanokuchi, Kaoru Midorikawa, Shinji Oikawa, Zhe Zhang, Ning Ma, Mariko Murata

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yiying Huang *Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, 514-8507, Mie, Japan.
Hatasu Kobayashi *Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, 514-8507, Mie, Japan.
Xiaoying ZhouLife Science Institute, Guangxi Medical University, Nanning, China.
Keiya MatsuokaDepartment of Acupuncture and Moxibution Science, Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Mie, Japan.
Jun KawanokuchiGraduate School of Health Science, Suzuka University of Medical Science, Suzuka, 513-8670, Mie, Japan.
Kaoru MidorikawaDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, 514-8507, Mie, Japan.
Shinji OikawaDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, 514-8507, Mie, Japan.
Zhe ZhangDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Ning MaGraduate School of Health Science, Suzuka University of Medical Science, Suzuka, 513-8670, Mie, Japan. maning@suzuka-u.ac.jp.
Mariko MurataDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, 514-8507, Mie, Japan. mmurata@med.mie-u.ac.jp.

Funding

Ministry of Education, Culture, Sports, Science and Technology 23K24589
6 · The paper itself

Abstract

Taurine is a semi-essential amino acid with diverse cytoprotective effects and is associated with anti-aging. This study explores the role and molecular mechanism of taurine in muscle aging. Senescence-accelerated mouse prone 8 (SAMP8) and its resistant (senescence-accelerated mouse resistant 1, SAMR1) mice were given 1% taurine water from 5 to 10 months of age, while control mice were given distilled water (DW). At 10 months of age, a rotarod test was performed to assess muscle endurance. SAMP8 mice had a shorter running time on the rotarod test than SAMR1 mice. Taurine significantly extended running time compared with that of DW-drinking group in SAMP8 mice, a similar trend was observed in SAMR1 mice. The gastrocnemius muscle was used for the RNA-sequencing analysis. Among differentially expressed genes between taurine and DW, Tbx5 and Alb showed some significant differences between the treatment by RT-qPCR. Myoblast C2C12 cells underwent cellular senescence induction with D-galactose (D-gal), which was detected by SA-β-gal staining. Taurine reduced SA-β-gal-positive area induced by D-gal, suggesting its protective effect against cellular senescence. Myotube induction was inhibited by D-gal treatment and restored by taurine, as detected by immunocytochemistry of myosin heavy chain (MHC) and Western blot of myogenin. D-gal-induced decrease trend in protein level of TBX5 was significantly increased in C2C12 myotubes treated with taurine. Taurine may have a protective effect on muscle senescence and myotube regeneration.

Indexed as

AgingCellular SenescenceMuscle Fibers, SkeletalMuscle, SkeletalMyoblastsTaurineAnimalsCell LineMaleMiceTaurineSenescenceSkeletal muscleTaurineTBX5

Identifiers

PMID42360509
PMCPMC13582708

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.