ArticleExperimental brain research2026
Loading modulates monosynaptic transmission from spindle primary afferents to motoneurons in humans.
Article in Experimental brain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The literature does not provide a consistent account of how mechanical loading influences H-reflex excitability. Given the methodological diversity across previous studies, the present study investigated how different levels of mechanical load affect soleus H-reflex excitability during quiet stance in healthy adults. It incorporated several experimental controls to enhance the reliability and comparability of results. Eighteen participants were tested under five load conditions (10-100% of body weight) while maintaining a consistent M-wave amplitude and a relaxed muscle posture. H-reflex amplitude decreased progressively with increasing load, reaching significant suppression at full weight-bearing (F (4, 68) = 7.04, p < 0.001, partial η² = 0.293), whereas background EMG activity showed an opposite trend (χ² (4) = 26.97, p < 0.001). This dissociation suggests that muscle spindle-based spinal reflex excitability does not scale linearly with muscle activation, indicating enhanced premotoneuronal modulatory control under higher loading. These findings highlight that spinal circuits dynamically adjust reflexes to stabilise posture, prevent excessive contractions and fine motor control in response to increasing mechanical demands.
Indexed as
Identifiers
42360499What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.