ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026
Clinical utility of [
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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19 authors.
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Abstract
purposePrimary brain tumors are the most common solid neoplasms in children and young adults. Surgical resection remains the cornerstone of treatment, with extent of resection and histopathology serving as main prognostic factors. While magnetic resonance imaging (MRI) is the gold standard for neuroimaging and surgical planning, [
methodsWe retrospectively selected from a single-institutional registry 12 patients aged 16 years or younger who underwent surgical treatment for brain tumors at a single tertiary pediatric center between 2013 and 2024. All patients underwent preoperative [^18F]-FET PET in addition to MRI. PET findings were used to support biopsy targeting, surgical resection planning, and follow-up assessment. Histopathological and molecular diagnoses were reviewed according to the 2021 World Health Organization (WHO) classification of central nervous system.
resultsHistopathological diagnoses included low-grade gliomas and glioneuronal tumors, high-grade gliomas, diffuse midline glioma, and embryonal tumors. [^18F]-FET PET identified metabolically active neoplastic tissue in 11 of 12 patients. One false-positive finding occurred in a previously treated lesion and was ultimately attributed to reactive gliosis. PET/MRI integration supported surgical decision-making in all cases and proved particularly useful in differentiating tumor recurrence or progression from treatment-related changes during follow-up.
conclusionsIn this single-institution pediatric series, [
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