Evidence map›Paper›PMID 42360479›Full record

ArticleInternational journal of colorectal disease2026

Malignancy as a rising contributor to mortality in patients with inflammatory bowel disease: a population-based epidemiological study.

Amr Ahmed Aly Ibrahim, Mahmoud Shaaban Abdelgalil, Sara Hosny El-Farargy, Rahma Sameh Shaheen, Moaz Yasser Darwish, Ahmad Abdelrazek, Sara Metwally, Mohamed Adel Nassef, Karim Samir Attia, Mohamed Abd-ElGawad

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Article in International journal of colorectal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amr Ahmed Aly IbrahimFaculty of Medicine, Menoufiya University, Menoufiya, Egypt.
Mahmoud Shaaban AbdelgalilFaculty of Medicine, Ain-Shams University, Cairo, Egypt. 29908068800596@med.asu.edu.eg.
Sara Hosny El-FarargyFaculty of Medicine, Benha University, Benha, Egypt.
Rahma Sameh ShaheenFaculty of Medicine, Benha University, Benha, Egypt.
Moaz Yasser DarwishFaculty of Medicine, Fayoum University, Fayoum, Egypt.
Ahmad AbdelrazekCorewell Health Grosse Pointe Hospital, Grosse Pointe, Michigan, USA.
Sara MetwallyCorewell Health Grosse Pointe Hospital, Grosse Pointe, Michigan, USA.
Mohamed Adel NassefNational Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Karim Samir AttiaFaculty of Medicine, Ain-Shams University, Cairo, Egypt.
Mohamed Abd-ElGawadFaculty of Medicine, Fayoum University, Fayoum, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is associated with increased malignancy risk. This study assessed national trends in malignancy-related mortality among United States IBD patients from 1999 to 2020 using representative data.

methodsA retrospective, population-based analysis was conducted using the Centers for Disease Control and Prevention (CDC) Wide-ranging Online Data for Epidemiologic Research (WONDER) database. Deaths among individuals with IBD were identified using ICD-10 codes K50 and K51, while malignancy-related deaths were captured using codes C00-C97. Crude and Age-adjusted mortality rates (AMRs) were calculated and stratified by sex, ethnicity, region, state, and age group. Linear regression models evaluated trends and forecast malignancy-related mortality through 2030.

resultsBetween 1999 and 2020, 9,531 malignancy-related deaths occurred among IBD patients. Malignancy-related deaths rose significantly, increasing by 108.3% (p = 0.010, R

conclusionMalignancy is an increasingly important contributor to mortality among US IBD patients, particularly older adults, males, Midwest residents and White individuals. These findings highlight the need for enhanced cancer surveillance, equitable healthcare access, and integrated long-term management of IBD populations.

Indexed as

Inflammatory Bowel DiseasesNeoplasmsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMiddle AgedUnited StatesYoung AdultCDC WONDERCrohn’s diseaseInflammatory bowel diseaseMalignancyMortalityUlcerative colitis

Identifiers

PMID42360479
PMCPMC13309407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.