ArticleNeuroradiology2026
White matter microstructural alterations correlate with clinical characteristics in craniocervical dystonia.
Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundTo characterize white matter pathology, identify clinical correlates, and explore relevant biomarkers for deep brain stimulation (DBS) outcomes in craniocervical dystonia (CCD) using diffusion tensor imaging (DTI).
methodsWe involved 37 CCD patients (22 undergoing bilateral subthalamic DBS [STN-DBS]) and 42 matched healthy controls. Using Tract-Based Spatial Statistics (TBSS) for whole-brain analysis and Automated Fiber Quantification (AFQ) for 20 specific tracts, DTI measurements of fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) were extracted. Between-group metric comparisons and correlations with clinical features and treatment outcomes were assessed.
resultsTBSS revealed reduced FA in left anterior corona radiata and right posterior thalamic radiation, increased AD in splenium of corpus callosum, and widespread elevated MD/RD (p < 0.0125, family-wise error combined threshold-free cluster enhancement corrected). AFQ identified segmental increased MD/RD across several tracts, most notably within anterior thalamus radiation (ATR), corticospinal tract, cingulum cingulate, callosum forceps, and inferior fronto-occipital fasciculus (uncorrected p < 0.01). Microstructural alterations correlated with earlier disease onset, severe baseline blepharospasm, and botulinum toxin exposure (p < 0.01, uncorrected). Crucially, at an uncorrected threshold of p < 0.01, lower MD in the left ATR was associated with greater eye symptom improvement after STN-DBS surgery (r = -0.57, p = 0.009).
conclusionCCD exhibits distributed white matter microstructural alterations across multiple networks, potentially serving as the neurostructural substrate for motor and non-motor symptoms. Left ATR integrity is negatively associated with DBS outcomes.
Indexed as
Identifiers
42360457What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.