Evidence map›Paper›PMID 42360321›Full record

ArticleDiabetes care2026

A Novel Electronic Medical Record Search Method to Identify Patients With Ketosis-Prone Diabetes: Implications for Discovery of Atypical Diabetes.

Maaz Ahmed, Elizabeth Kubota-Mishra, Alejandro F Siller, Ansley Davis, Iliana Migacz, Stephanie Sisley, Jordana A Faruqi, Zeb I Saeed, Sarah Ahmed, Louis Philipson and 4 more

Abstract read
In one paragraph

Article in Diabetes care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maaz AhmedUniversity of Texas Health San Antonio, San Antonio, TX.
Elizabeth Kubota-MishraDepartment of Pediatrics, Division of Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
Alejandro F SillerDepartment of Pediatrics, Division of Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
Ansley DavisDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.
Iliana MigaczDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.
Stephanie SisleyDepartment of Pediatrics, Division of Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
Jordana A FaruqiDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.
Zeb I SaeedDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA.
Sarah AhmedNew York University, New York, NY.
Louis PhilipsonUniversity of Chicago Medicine, Chicago, IL.
Maria J RedondoDepartment of Pediatrics, Division of Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
Ashok BalasubramanyamDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.
Mustafa TosurDepartment of Pediatrics, Division of Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-2111-271X
RADIANT Study Group*

Funding

RARE and Atypical Diabetes Network(RADIANT)U54DK118638 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI ASHOK BALASUBRAMANYAM · 2018 to 2026
$22.7M
RADIANT Clinic and Data Coordinating CenterU54DK118612 · NIDDK · UNIVERSITY OF CHICAGO · PI Louis H. Philipson, Miriam Sargon Udler · 2018 to 2026
$21.9M
Investigation of Arginine Metabolism and Its Effects on Beta Cell Function in Children with Type 2 DiabetesK23DK129821 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Mustafa Tosur · 2022 to 2026
$932k
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K23 DK129821National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U54 DK118612National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U54 DK118638NIDDK NIH HHS K23 DK129821NIDDK NIH HHS U54 DK118612NIDDK NIH HHS U54 DK118638
6 · The paper itself

Abstract

We developed Python-based Expeditious Program for Parsing Electronic Records (PEPPER) as a novel electronic medical record (EMR) search tool. We tested its utility and efficiency to automate the first step of identifying patients with A-β+ ketosis-prone diabetes (KPD). Electronic charts of 1,660 youth with type 2 diabetes (T2D) were analyzed by PEPPER to identify those with diabetic ketoacidosis (DKA) within 6 months of diagnosis. The efficiency and accuracy of PEPPER were compared with manual review. Further review confirmed A-β+ KPD per the Rare and Atypical Diabetes Network criteria. PEPPER identified 110 youth with T2D and DKA, of whom 21 met full A-β+ KPD criteria. PEPPER significantly reduced chart review time for this initial critical step compared with manual searching (mean ± SD 13.4 ± 3.9 s vs. 26.6 ± 9.4 s per chart; P < 0.001), and was 100% accurate. PEPPER streamlines EMR review, significantly reducing manual effort without sacrificing accuracy.

Indexed as

Diabetes Mellitus, Type 2Diabetic KetoacidosisElectronic Health RecordsAdolescentChildFemaleHumansMale

Identifiers

PMID42360321
PMCPMC13493332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.