Evidence map›Paper›PMID 42360287›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Cognitive decline in Dutch-type hereditary and sporadic cerebral amyloid angiopathy: a 5-year follow-up study.

Rosemarie van Dort, Vera C J van Stek-Smits, Sanne E Schriemer, Reinier G J van der Zwet, Manon R Schipper, Sabine Voigt, Ellen P Hart, Vandhana Easwaran, Hamid R Sohrabi, Kevin Taddei and 7 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

17 authors.

Rosemarie van DortDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.ORCID https://orcid.org/0000-0002-7777-3189
Vera C J van Stek-SmitsDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Sanne E SchriemerDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Reinier G J van der ZwetDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Manon R SchipperDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Sabine VoigtDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Ellen P HartDirectorate of Research and Valorisation, Leiden University Medical Center, Leiden, The Netherlands.
Vandhana EaswaranSchool of Psychology, College of Health and Education, Murdoch University, Perth, Western Australia, Australia.
Hamid R SohrabiSchool of Psychology, College of Health and Education, Murdoch University, Perth, Western Australia, Australia.
Kevin TaddeiAlzheimer's Research Australia, Perth, Western Australia, Australia.
Samantha L GardenerAlzheimer's Research Australia, Perth, Western Australia, Australia.
Ralph N MartinsCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.
Steven M GreenbergMassachusetts General Hospital and Harvard Medical School, Harvard University, Boston, Massachusetts, USA.
Matthias J P van OschDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Marianne A A van WalderveenDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Marieke J H WermerDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Ellis S van EttenDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Funding

Dutch Heart Foundation 2016T086TRACK D-CAA consortium
6 · The paper itself

Abstract

introductionCerebral amyloid angiopathy (CAA) is associated with cognitive impairment, but its longitudinal course of cognitive decline remains unclear. We investigated domain-specific cognitive trajectories in Dutch-type hereditary (D-CAA) and sporadic CAA (sCAA) to compare patterns and rates of decline.

methodsWe included 181 participants - 93 D-CAA mutation carriers (59 without, 34 with prior intracerebral hemorrhage [ICH]) and 88 with sCAA (57 without, 31 with ICH) - who underwent annual neuropsychological assessment. Longitudinal change in global cognition, memory, processing speed, and executive function was analyzed using linear mixed models.

resultsOver 5 years, cognitive decline was subtle but measurable. Memory and processing speed declined in D-CAA with prior ICH, whereas D-CAA without ICH and sCAA remained relatively stable. Global cognition showed a modest but significant decline, while executive function remained stable. DISCUSSION: CAA-related cognitive decline appears domain- and stage-dependent, suggesting progressive small-vessel injury rather than acute hemorrhage may drive deterioration.

Indexed as

Cerebral Amyloid AngiopathyCerebral Amyloid Angiopathy, FamilialCognitive DysfunctionAgedCerebral HemorrhageDisease ProgressionExecutive FunctionFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsProcessing Speedamyloid beta (Aβ) depositioncerebral amyloid angiopathycerebral small‐vessel disease (CSVD)cognitive declinecognitive impairmentDutch‐type cerebral amyloid angiopathy (D‐CAA)hereditary CAAintracerebral hemorrhage (ICH)neurodegenerationsporadic cerebral amyloid angiopathy (sCAA)vascular cognitive impairment

Identifiers

PMID42360287
PMCPMC13307620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.