ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2026
Cell-based therapy injections for the management of knee osteoarthritis: The ESSKA-ICRS consensus. Recommendations using the RAND/UCLA appropriateness method for different clinical scenarios.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Funding
Abstract
purposeThe aim of this consensus was to develop evidence/expert-based patient-focused recommendations on the appropriateness of intra-articular point-of-care (POC) cell-based therapy (CBT) injections in different clinical scenarios of patients with knee osteoarthritis (OA).
methodsThe RAND/UCLA Appropriateness Method was used by European experts of the European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA) and the International Cartilage Regeneration and Joint Preservation Society (ICRS) to reach a consensus and produce recommendations for specific patient categories, combining best available scientific evidence with the collective judgement of a panel of experts.
resultsA total of 144 scenarios were developed based on five factors: cell source (bone marrow vs. adipose tissue), age (<50 vs. 50-65 vs. 66-80 vs. >80 years), joint involvement (prevalent tibio-femoral vs. patello-femoral), OA level (Kellgren-Lawrence [KL] Grade 0-I vs. II-III vs. IV) and body mass index (BMI) (<18.5 vs. 18.5-35 vs. >35 kg/m
conclusionsThis ESSKA-ICRS expert consensus provides recommendations on the appropriateness of cell-based injectable therapies for knee OA. POC-CBT may be considered, after failure of other non-operative and injectable options, in patients aged ≤65 years with BMI ≤ 35 kg/m LEVEL OF EVIDENCE: Level I.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.