Evidence map›Paper›PMID 42360165›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Risk and protective factors for cognitive decline in older adults from a nationally representative sample in India: Results from the LASI-DAD.

Alden L Gross, Emma Nichols, Miguel Arce Rentería, Pranali Y Khobragade, Erik Meijer, Sarah Petrosyan, Mathew Varghese, Albert Weerman, Peifeng Hu, Joyita Banerjee and 36 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

46 authors.

Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-4678-0562
Emma NicholsCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Miguel Arce RenteríaTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York City, New York, USA.
Pranali Y KhobragadeCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Erik MeijerCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Sarah PetrosyanCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Mathew VargheseDepartment of Psychiatry, St. John Medical College, Bengaluru, Karnataka, India.
Albert WeermanCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Peifeng HuDivision of Geriatric Medicine, University of California, Los Angeles, California, USA.
Joyita BanerjeeCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Sandy ChienCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Marco AngrisaniCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Anushikha DhankharCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Harrshita VishwakarrmaDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Istikhar AliVenu Geriatric Institute, Delhi, India.
Ziqi ZhouCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Rajeev AravindakshanAll India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India.
Sankha Shubhra ChakrabartiInstitute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Madhumita Priyadarshini DasGauhati Medical College, Guwahati, Assam, India.
Karishma DeAster Malabar Institute of Medical Sciences, Kannur, Kerala, India.
Minakshi DharAll India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Gevesh C DewanganAll India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Monica GuptaDepartment of General Medicine, Government Medical College and Hospital, Chandigarh, India.
Umar Hafiz KhanSher-e Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
Vishakha JainAll India Institute of Medical Sciences, Bibinagar, Telangana, India.
John P JohnDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Ravi KirtiAll India Institute of Medical Sciences, Patna, Bihar, India.
Arun KokaneAll India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Sarabmeet Singh LehlDepartment of General Medicine, Government Medical College and Hospital, Chandigarh, India.
Rashmi R MohantyAll India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Vinay PanditAll India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Chhaya RajguruGrants Medical College & JJ Hospital, Mumbai, Maharashtra, India.
Durgesh Prasad SahooAll India Institute of Medical Sciences, Bibinagar, Telangana, India.
Lalit SankheGrants Medical College & JJ Hospital, Mumbai, Maharashtra, India.
M SukumarAll India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Arunansu TalukdarGeriatric Medicine Department, Medical College, Kolkata, West Bengal, India.
Venugopalan GunasekaranJawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
T V SekherInternational Institute for Population Sciences, Mumbai, India.
David E BloomDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Kenneth M LangaDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Palanimuthu T SivakumarDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Mary GanguliDepartment of Psychiatry, Neurology, and Epidemiology, University of Pittsburgh School of Medicine and School of Public Health, Pittsburgh, Pennsylvania, USA.
Eileen M CrimminsLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Sharmistha DeyDepartment of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Aparajit Ballav DeyVenu Geriatric Institute, Delhi, India.
Jinkook LeeCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.

Funding

Integrting Information About Aging SurveysR01AG030153 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, Alden L. Gross · 2007 to 2026
$41.7M
Leveraging a natural experiment to estimate the causal impact of blood sugar on dementia and cognition in IndiaR01AG051125 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jinkook Lee · 2015 to 2026
$26.8M
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.U01AG064948 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KARDIA, SHARON L, LEE, JINKOOK · 2019 to 2023
$12.5M
Socioeconomic, Cardiovascular, and Psychosocial Sources of Cross-National Variation in Cognitive Health Among Older AdultsR01AG070953 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alden L. Gross, Lindsay C Kobayashi · 2021 to 2026
$4.6M
NIA NIH HHS R01 AG030153NIA NIH HHS R01 AG051125NIA NIH HHS R01 AG070953NIA NIH HHS U01 AG064948
6 · The paper itself

Abstract

introductionWe characterized modifiable risk and protective factors for cognitive decline in India.

methodsUsing the first nationally representative population-based longitudinal sample of N = 6168 older adults in India, we evaluated associations of risk factors (demographic characteristics, self-reported and objective health characteristics, health behaviors, and sensory function) for late-life cognitive decline with up to 6.4 years of follow-up (range: 2.8 to 6.4 years).

resultsThe mean rate of general cognitive decline was -0.029 SD per year and was progressively steeper with age. Most risk factors, particularly demographic and cardiovascular characteristics, were associated with steeper cognitive decline in expected directions: Associations of history of high cholesterol or heart attack on rate of cognitive decline, for example, were comparable to being 8 to 10 years older. DISCUSSION: Most risk factors were associated with change in expected directions, highlighting the potential generalizability to India of previously identified risk factors for dementia.

Indexed as

AgingCognitive DysfunctionAgedAged, 80 and overFemaleHumansIndiaLongitudinal StudiesMaleMiddle AgedProtective FactorsRisk Factorscognitive declineDiagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI‐DAD)gerontologyHarmonized Cognitive Assessment Protocol (HCAP)India

Identifiers

PMID42360165
PMCPMC13307323

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.