ArticleAngewandte Chemie (International ed. in English)2026
Pre-Crosslinked Network-Mediated Dual Exchange Enables Boosting Chiroptical Activity and Decoupled Two-Level Chirality in Covalent Organic Frameworks.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The construction of crystalline covalent organic frameworks (COFs) with strong and tunable chiroptical responses remains challenging due to rapid crystallization that limits effective chirality induction. Here, we report a pre-crosslinked network-mediated dual-exchange strategy that enables both amplified chiroptical activity and decoupled multilevel chirality in β-ketoenamine-linked COFs. In this approach, monomers are first immobilized within a pre-crosslinked amorphous imine network, which kinetically regulates subsequent framework formation. The crystallization proceeds through a dual-exchange process involving concurrent amine and aldehyde exchange, thereby retarding reaction kinetics and prolonging the chirality induction window. As a result, the obtained COFs exhibit pronounced propeller-like conformational chirality with dissymmetry factors (|g
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