Evidence map›Paper›PMID 42360098›Full record

ArticleNMR in biomedicine2026

Metabolic Assessment in Human Pluripotent Stem Cell-Derived Cerebral Organoids Using HR-MAS NMR Spectroscopy.

Maria Alejandra Castilla Bolanos, Vorapin Chinchalongporn, Rajshree Ghosh Biswas, Colleen Bailey, Maggie Wu, Ronald Soong, Fermisk Saleh, Andre Simpson, Carol Schuurmans, Jamie Near

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Alejandra Castilla BolanosSunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0001-8204-4610
Vorapin ChinchalongpornSunnybrook Research Institute, Toronto, Ontario, Canada.
Rajshree Ghosh BiswasDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Colleen BaileySunnybrook Research Institute, Toronto, Ontario, Canada.
Maggie WuSunnybrook Research Institute, Toronto, Ontario, Canada.
Ronald SoongDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Fermisk SalehSunnybrook Research Institute, Toronto, Ontario, Canada.
Andre SimpsonDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8247-5450
Carol SchuurmansSunnybrook Research Institute, Toronto, Ontario, Canada.
Jamie NearSunnybrook Research Institute, Toronto, Ontario, Canada.

Funding

CIHR PJT-183715New Frontiers in Research Fund NFRFT-2022-00327
6 · The paper itself

Abstract

Brain metabolism is vital to healthy brain function and is often altered in disease; yet direct investigation in patients is challenging. Although animal models are commonly used for studying brain metabolism, their use is under increasing scrutiny due to concerns of animal welfare and model validity. Human pluripotent stem cell (hPSC)-derived cerebral organoids (COs) present a unique opportunity to model human brain developmental and neuropathological processes, allowing for detailed metabolic characterization via multiple approaches. Here, we applied high-resolution magic-angle spinning (HR-MAS) proton nuclear magnetic resonance (

Indexed as

BrainOrganoidsPluripotent Stem CellsProton Magnetic Resonance SpectroscopyHumansMagnetic Resonance Spectroscopycerebral organoidshuman brain modelhuman pluripotent stem cellsmetabolismNMR spectroscopy

Identifiers

PMID42360098
PMCPMC13307635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.