Evidence map›Paper›PMID 42359911›Full record

ArticleOrganic & biomolecular chemistry2026

Synthesis and evaluation of 4-(α-arylvinyl)pyridines as activated linker groups for application in antibody-drug conjugates.

Jack Andrew, James M Sharpe, Matthew Wallace, Jenny Thirlway, Patrick L Kerigan Higgs, G Richard Stephenson, Thomas E Storr, Christopher J Richards

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jack AndrewSchool of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich, NR4 7TJ, UK. chris.richards@uea.ac.uk.
James M SharpeSchool of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich, NR4 7TJ, UK. chris.richards@uea.ac.uk.
Matthew WallaceSchool of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich, NR4 7TJ, UK. chris.richards@uea.ac.uk.ORCID 0000-0002-5751-1827
Jenny ThirlwayIksuda Therapeutics Ltd, The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK.
Patrick L Kerigan HiggsIksuda Therapeutics Ltd, The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK.
G Richard StephensonSchool of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich, NR4 7TJ, UK. chris.richards@uea.ac.uk.
Thomas E StorrSchool of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich, NR4 7TJ, UK. chris.richards@uea.ac.uk.
Christopher J RichardsSchool of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich, NR4 7TJ, UK. chris.richards@uea.ac.uk.ORCID 0000-0001-7899-4082

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the aim of increasing the cysteine-selective bioconjugation reactivity of 4-vinylpyridines, a series of 4-(α-arylvinyl)pyridines were synthesised by Suzuki-Miyaura cross-coupling of 4-(α-bromovinyl)pyridine. The rate of thia-Michael addition of cysteine-containing glutathione correlated with

Indexed as

ImmunoconjugatesPyridinesGlutathioneMolecular StructureGlutathioneImmunoconjugatesPyridines

Identifiers

PMID42359911
PMCPMC13307478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.