ArticleJournal of feline medicine and surgery2026
Longitudinal evaluation of discordant symmetric dimethylarginine and creatinine as markers of glomerular filtration rate in radioiodine-treated hyperthyroid cats.
Article in Journal of feline medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectivesThe aim of the present study was to determine the frequency and clinical significance of discordant serum symmetric dimethylarginine (SDMA) and creatinine concentrations relative to glomerular filtration rate (GFR) in mature and senior hyperthyroid cats treated with radioactive iodine (RAI). Secondary aims of the study were to compare the sensitivity and specificity of two SDMA upper reference intervals (RIs; >14 and ⩾18 µg/dl) and creatinine (⩾175 µmol/l) for detecting decreased GFR and to evaluate the intra-individual variability of both biomarkers.MethodsA prospective longitudinal study of 27 client-owned hyperthyroid cats receiving low-dose RAI therapy was conducted. At baseline, 1, 6 and 12 months after RAI, cats were evaluated for thyroid status, GFR, SDMA and creatinine concentrations. Discordance was defined as one renal biomarker exceeding its RI with the other within/below the RI, using laboratory and age-specific SDMA RIs. In euthyroid cats, sensitivity, specificity and predictive values of SDMA/creatinine for decreased GFR and intra-individual variability were determined.ResultsDiscordance between SDMA and creatinine was in the range of 10-75% and was highest with the SDMA limit >14 µg/dl. SDMA-GFR discordance exceeded creatinine-GFR discordance at all time points and was highest at baseline, when all cats were hyperthyroid. In cats with euthyroid status at 12 months, SDMA >14 µg/dl was more sensitive (83%) but less specific (50%) for decreased GFR than SDMA ≥18 µg/dl (sensitivity 50%, specificity 71%) and creatinine (sensitivity 50%, specificity 85%). Intra-individual variability was similar for both biomarkers (~15%).Conclusions and relevanceDiscordant SDMA and creatinine concentrations are frequent in older hyperthyroid cats and are influenced by thyroid status and SDMA RIs, complicating interpretation. The SDMA limit ≥18 µg/dl improves specificity for decreased GFR and is more appropriate for senior cats. SDMA concentrations in the range of 15-18 µg/dl are less likely to reflect true GFR reduction when creatinine is normal; therefore, non-renal influences such as hyperthyroidism should be considered and ongoing monitoring of renal parameters is recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.