ReviewDental research journal2026
Optimizing orthodontic results with low-intensity pulsed ultrasound: A literature review.
Review in Dental research journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Low-intensity pulsed ultrasound (LIPUS) has gained recognition as a noninvasive, Food and Drug Administration-approved therapeutic modality with diverse clinical applications, including in orthodontics. This review aims to summarize the benefits and mechanisms of LIPUS in various aspects of orthodontic care. Materials and Methods: A comprehensive literature search was conducted across multiple databases (Web of Science, PubMed, Embase, and Cochrane Library), focusing on randomized controlled trials, clinical studies, and experimental research from 2004 to 2024. Results: LIPUS has been shown to significantly accelerate orthodontic tooth movement, reduce treatment duration by up to 49%, and improve patient compliance. It works by enhancing bone remodeling, stimulating osteoblast and osteoclast activity, and increasing the expression of bone-forming and resorptive proteins. LIPUS also addresses orthodontically induced inflammatory root resorption, promoting the repair of cementum and reducing root damage through mechanisms involving osteoprotegerin and receptor activator of nuclear factor kappa-ligand signaling. Furthermore, LIPUS is effective in alleviating pain associated with orthodontic treatments by promoting tissue healing and reducing inflammation. In orthognathic surgery, LIPUS accelerates bone regeneration and tissue recovery, improving outcomes such as reduced swelling and enhanced bone healing. The application of LIPUS also supports the stability of miniscrews, a critical factor in orthodontic anchorage, by increasing bone-screw contact and reducing screw mobility. In addition, LIPUS enhances the effectiveness of functional orthopedic treatments in growing patients with skeletal malocclusions, promoting mandibular growth and improving treatment outcomes. Conclusion: Overall, LIPUS proves to be a promising adjunct in orthodontics, with wide-ranging benefits including accelerated tooth movement, reduced root resorption, pain relief, and improved surgical recovery, making it an effective tool in contemporary orthodontic practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.