ArticleTherapeutic advances in medical oncology2026
Real-world outcomes of FOLFIRINOX versus gemcitabine plus nab-paclitaxel and prognostic factors in advanced pancreatic cancer: a retrospective cohort study.
Article in Therapeutic advances in medical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: FOLFIRINOX (FFX) and gemcitabine plus nab-paclitaxel (GnP) are the main first-line regimens for advanced pancreatic adenocarcinoma. No randomized clinical trials have directly compared their efficacy, and real-world data remain limited. Objectives: The primary endpoint of this study was to compare overall survival (OS) and progression-free survival (PFS) between the two regimens. Secondary endpoints included the objective response rate (ORR) and the identification of prognostic factors. Design: Retrospective, single-center cohort study. Methods: Patients with locally advanced or metastatic pancreatic adenocarcinoma treated with first-line FFX or GnP at a tertiary referral center in Spain between 2011 and 2024 were included. OS and PFS were estimated using the Kaplan-Meier method and compared with the log-rank test. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard models. Propensity score matching was performed as a sensitivity analysis. Results: A total of 200 patients were analyzed (FFX, Conclusion: In this real-world cohort, FFX and GnP were associated with similar OS and PFS outcomes. The retrospective design and baseline imbalances between groups limit causal inference due to potential residual confounding and selection bias.
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