Evidence map›Paper›PMID 42359319›Full record

ArticleSchizophrenia research. Cognition2026

Cognitive pathways to communicative-pragmatic dysfunction in schizophrenia: The role of autistic symptoms.

G Agostoni, M F D'Incalci, M Bechi, J Sapienza, M Spangaro, V Cirulli, M Buonocore, F Martini, F Frau, C Barattieri di San Pietro and 6 more

Abstract read
In one paragraph

Article in Schizophrenia research. Cognition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

G AgostoniSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
M F D'IncalciSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
M BechiSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
J SapienzaSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
M SpangaroSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
V CirulliSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
M BuonocoreSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
F MartiniSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
F FrauLaboratory of Neurolinguistics and Experimental Pragmatics (NEP), Department of Humanities and Life Sciences, University School for Advanced Studies IUSS, Pavia, Italy.
C Barattieri di San PietroLaboratory of Neurolinguistics and Experimental Pragmatics (NEP), Department of Humanities and Life Sciences, University School for Advanced Studies IUSS, Pavia, Italy.
L BischettiLaboratory of Neurolinguistics and Experimental Pragmatics (NEP), Department of Humanities and Life Sciences, University School for Advanced Studies IUSS, Pavia, Italy.
C GuglielminoSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
F CocchiSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
R CavallaroSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
V BambiniLaboratory of Neurolinguistics and Experimental Pragmatics (NEP), Department of Humanities and Life Sciences, University School for Advanced Studies IUSS, Pavia, Italy.
M BosiaSchizophrenia Research and Clinical Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Communicative-pragmatic dysfunction is recognized as a core feature of schizophrenia, as well as a hallmark of Autism Spectrum Disorders (ASD), strongly intertwined with neurocognitive and sociocognitive domains. Autistic symptoms, i.e., autistic-like traits below ASD diagnostic threshold, occur in over 50% of patients with schizophrenia, affecting social cognition and functioning. Strikingly, their specific link with pragmatics remains unexplored. This study tests the relationship between autistic symptoms and pragmatics in schizophrenia, modelling their interplay with executive functions (EF) and Theory of Mind (ToM), in the context of the sprout model of pragmatics. Methods: A sample of 125 individuals with schizophrenia was assessed for autistic symptoms, pragmatics, ToM, and EF. Path analysis examined direct and indirect effects of autistic symptoms on global pragmatics and on pragmatic production and comprehension, with EF and ToM as mediating variables. Results: Autistic symptoms were negatively associated with EF, ToM, and pragmatics. Path analysis revealed that autistic symptoms have a direct effect on global pragmatics, as well as an indirect one, via EF and ToM consecutively. Furthermore, autistic symptoms indirectly affected both pragmatic production, via EF, and comprehension, through EF and ToM sequentially. Conclusions: Results show a strong link between autistic symptoms and pragmatics in schizophrenia, highlighting a cognitive pathway from EF to ToM in supporting pragmatics, in line with the sprout model, with a key role of the former in production and of the latter in comprehension. Clinically, this study highlights that assessing autistic symptoms in routine care may help identify patients at higher risk for pragmatic deficits and guide targeted rehabilitation strategies.

Indexed as

Autism Spectrum DisorderExecutive functionsLanguagePsychosisTheory of Mind

Identifiers

PMID42359319
PMCPMC13292262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.