Analyzing the 'bradykinesia complex' in GBA1-associated Parkinson's disease: A series of three cases.

Martina De Riggi, Daniele Birreci, Adriana Martini, Simone Aloisio, Luca Angelini, Anna Sofia Grandolfo, Matteo Bologna

Abstract readLetter

In one paragraph

Article in Clinical parkinsonism & related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Martina De RiggiDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Daniele BirreciDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Adriana MartiniDepartment of Neurology and Stroke Unit, San Camillo de Lellis, General District Hospital, Rieti, Italy.

Simone AloisioDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Luca AngeliniIRCCS Neuromed, Pozzilli, (IS), Italy.

Anna Sofia GrandolfoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Matteo BolognaDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

"Although GBA1-associated Parkinson's disease shows distinctive clinical features, the characterization of motor impairment remains limited. We performed OFF- and ON-state kinematic finger-tapping analysis in three Parkinson's disease patients carrying GBA1 variants of different severity, applying the 'bradykinesia complex' framework. Quantitative assessment revealed heterogeneous kinematic profiles and variable dopaminergic responsiveness. These findings suggest that kinematic biomarkers may complement clinical evaluation and support phenotypic characterization in GBA1-associated Parkinson's disease."

Indexed as

Bradykinesia complex, movement disordersFinger tappingGBA1Genotype–phenotype correlationKinematic analysisParkinson's disease

Identifiers

PMID42359245

DOI10.1016/j.prdoa.2026.100462

PMCPMC13292783

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