ArticleCureus2026
Hypokalemic Periodic Paralysis Syndrome.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypokalemic periodic paralysis (HPP) is a rare neuromuscular disorder characterized by recurrent episodes of acute muscle weakness or paralysis secondary to hypokalemia. Attacks are often triggered by metabolic or physiologic stressors and may require critical care management. We present two cases of HPP, highlighting challenges in management. A 22-year-old male and a 42-year-old male presented with severe hypokalemia and acute flaccid paralysis requiring intensive care unit admission due to profoundly low potassium levels. Both patients required aggressive repletion with symptom resolution. Despite continued outpatient management, both patients re-presented within one to two months with recurrent episodes requiring repeat hospitalization. HPP results from skeletal muscle ion channel dysfunction leading to episodic paralysis. Management is challenging due to the narrow therapeutic correction window and unpredictable recurrent attacks. These cases highlight the need for standardized protocols and long-term strategies to improve outcomes, along with reducing recurrence and complications.
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