Evidence map›Paper›PMID 42359139›Full record

SynthesisFrontiers in public health2026

Effects of different iodine supplementation strategies on thyroid function in iodine-deficient pregnant women: a meta-analysis.

Yingying Lv, Baiming Jin, Jiazhuang Guo, Jingshu Bu, Chen Chen, Yunfeng Han, Zhiping Xie, Yuehui Jia, Siyuan Wan, Chunjing Zhang

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yingying LvSchool of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Baiming JinSchool of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Jiazhuang GuoSchool of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Jingshu BuSchool of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Chen ChenSchool of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Yunfeng HanSchool of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Zhiping XieSchool of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Yuehui JiaSchool of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Siyuan WanSchool of Public Health, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Chunjing ZhangPostdoctoral Workstation, Research Institute of Medical and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to clarify the association between iodine supplementation and thyroid function indices, as well as secondary outcomes including thyroglobulin (Tg) and thyroid volume (TV), in iodine-deficient pregnant women, accounting for different supplementation regimens and trimesters. Methods: Chinese and English literature on iodine supplementation in iodine-deficient pregnant women and its associations with thyroid function indices, Tg, and TV was retrieved from PubMed, Medline, Embase, CNKI, WanFang, and WeiPu databases. Effect sizes were estimated using fixed- and random-effects models, reported as standardized mean difference (SMD), odds ratio (OR), and 95% confidence intervals (CIs). Results: Iodine supplementation was associated with reduced serum TSH and Tg levels in iodine-deficient pregnant women (TSH: SMD = -0.14, 95% CI: -0.23, -0.05; Conclusion: Standardized iodine supplementation notably reduces serum TSH and Tg in iodine-deficient pregnant women, relieving gestational thyroid dysfunction and optimizing maternal thyroid health. Greater TSH improvements are observed in Asian populations, the third trimester, and those taking 200-300 μg potassium iodide daily. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261323017, identifier: CRD420261323017.

Indexed as

Dietary SupplementsIodinePregnancy ComplicationsThyroid GlandFemaleHumansPregnancyThyroglobulinThyroid Function TestsThyrotropinIodineThyroglobulinThyrotropiniodine deficientiodine supplementationmeta-analysispregnant womenthyroglobulinthyroid functionthyroid volume

Identifiers

PMID42359139
PMCPMC13291067

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.