Cerebrospinal fluid glucose-to-lactate ratio (CGLR) as a diagnostic biomarker for postoperative intracranial infections in patients with acute brain injury: a prospective diagnostic accuracy study.

Weidong Wang, Huajun Wang, Chengjie Zhou, Ye Fu

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Weidong WangDepartment of Intensive Care Unit, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

Huajun WangDepartment of Intensive Care Unit, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

Chengjie ZhouDepartment of Intensive Care Unit, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

Ye FuDepartment of Intensive Care Unit, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

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6 · The paper itself

Abstract

Objectives: The aim of this study was to evaluate the diagnostic accuracy of the cerebrospinal fluid glucose-to-lactate ratio (CGLR) for detecting postoperative intracranial infections in patients with acute brain injury (ABI) and compare it with conventional biomarkers. Methods: A single-center prospective study was conducted with 121 postoperative ABI patients suspected of infection. Cerebrospinal fluid (CSF) and peripheral blood samples were collected under aseptic conditions. Levels of CSF lactate (cLac), CSF glucose (cGlu), CSF procalcitonin (PCT), and CGLR were measured. Results: The AUC values for cGlu and cLac were 0.836 and 0.820, respectively, with optimal cutoffs of 2.6 mmol⋅L Conclusion: CGLR is a rapid, cost-effective, and reliable biomarker for diagnosing postoperative intracranial infections in ABI patients. It outperforms traditional markers and remains unaffected by peripheral glucose fluctuations.

Indexed as

acute brain injurycerebrospinal fluid glucosecerebrospinal fluid glucose-to-lactatecerebrospinal fluid lactatepostoperative intracranial infection

Identifiers

PMID42359084

DOI10.3389/fmed.2026.1830485

PMCPMC13291026

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