ArticleFrontiers in medicine2026
Research landscape, hotspots, and evolutionary trends of knee osteoarthritis and oxidative stress: a multidimensional bibliometric analysis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to analyze the research status, hotspots, and development trends in the field of KOA and oxidative stress using a multidimensional bibliometric approach. Methods: Literature related to KOA and oxidative stress was retrieved from the Web of Science Core Collection. CiteSpace, VOSviewer, and RStudio were employed to analyze publication volume, scientific collaboration networks, keyword co-occurrence, clustering, and the characteristics of hotspot shifts, with the goal of revealing the overall research landscape of KOA and oxidative stress. Results: Research volume on KOA and oxidative stress has entered a phase of rapid expansion, peaking in 2024. While China leads in total publication output, its relatively low centrality (0.06) combined with a low global institutional network density (0.0061) reveals a "high-output, low-integration" pattern, indicating significant potential for enhanced international synergy. Key knowledge hubs are centered around institutions like Nanjing University of Chinese Medicine and Universidade da Coruña, with leading scholars such as Blanco FJ and Li J driving the field's intellectual core. Keyword clustering identifies a three-dimensional thematic landscape: nutritional intervention (e.g., vitamin E), mechanistic exploration (e.g., cell senescence), and therapeutic investigation (e.g., ozone). The research evolution follows a clear trajectory of "foundational validation → mechanistic refinement → translational expansion," with current frontiers shifting from localized joint mechanisms toward systemic-local interactions. Conclusion: The field of KOA and oxidative stress is characterized by an internationally collaborative yet resource-fragmented research landscape. Its evolution follows a logic of initial foundational validation, followed by mechanistic refinement, and finally translational expansion. Future efforts should strengthen interdisciplinary collaboration and promote multicenter clinical translational research, which holds promise for developing more targeted and effective novel strategies for the diagnosis and treatment of KOA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.