Evidence map›Paper›PMID 42358928›Full record

ArticleFrontiers in neurology

Impacts of repetitive transcranial magnetic stimulation parameters on cerebral hemodynamics in patients with disorders of consciousness.

Hao Peng, Shuai Han, Yilin Zhang, Aoxuan Liu, Fenglin Wu, Mingrui Dong, Siping Wang, Qianqian Ge, Long Xu, Jianghong He and 1 more

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Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hao PengSchool of Instrumentation Science and Opto-Electronics Engineering, Beijing Information Science and Technology University, Beijing, China.
Shuai HanDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yilin ZhangSchool of Instrumentation Science and Opto-Electronics Engineering, Beijing Information Science and Technology University, Beijing, China.
Aoxuan LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Fenglin WuSchool of Instrumentation Science and Opto-Electronics Engineering, Beijing Information Science and Technology University, Beijing, China.
Mingrui DongSchool of Instrumentation Science and Opto-Electronics Engineering, Beijing Information Science and Technology University, Beijing, China.
Siping WangSchool of Instrumentation Science and Opto-Electronics Engineering, Beijing Information Science and Technology University, Beijing, China.
Qianqian GeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Long XuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jianghong HeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Juanning SiSchool of Instrumentation Science and Opto-Electronics Engineering, Beijing Information Science and Technology University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising noninvasive neuromodulation technique for patients with disorders of consciousness (DOC). However, the specific effects of rTMS stimulation parameters on this population remain insufficiently characterized. Objectives: Functional near-infrared spectroscopy (fNIRS) was used to evaluate the real-time and short-term effects of rTMS with different stimulation parameters on patients with DOC. Methods: The hemodynamic data were acquired from 20 patients with DOC during rTMS at different frequencies (10 Hz and 20 Hz) and different target sites (at F3 and F4), yielding four experimental conditions. The spatiotemporal characteristics of hemodynamics across these conditions were quantitatively compared to investigate the real-time and short-term after-effects of rTMS. Results: Results showed that the hemodynamic responses significantly increased following the high- frequency (both 10 Hz and 20 Hz) rTMS. With a fixed total number of stimulation pulses, the lower-frequency, longer-duration protocol (10 Hz, 10 s) produced stronger hemodynamic responses than the higher-frequency, shorter-duration protocol (20 Hz, 5 s) across measured brain areas. Notably, rTMS applied to either the left (F3) or right (F4) DLPFC evoked significantly stronger ipsilateral than contralateral hemodynamic responses, indicating a lateralized neuromodulation effect. Conclusion: The fNIRS-based monitoring offers a valuable method for evaluating the neuromodulation efficacy of rTMS, providing a novel perspective for optimizing neuromodulation parameters for patients with DOC.

Indexed as

disorders of consciousnessfunctional near-infrared spectroscopyhemodynamic responsesrepetitive transcranial magnetic stimulationstimulation parameters

Identifiers

PMID42358928
PMCPMC13290451

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.