Evidence map›Paper›PMID 42358716›Full record

ArticleJACS Au2026

Ultrafast Excited-State Dynamics and Two-Photon Near-Infrared Induced Photodynamic Therapy Performance of 5‑Phenylethynyl-4-thiouridine.

Shuo Wang, Qian Zhou, Guang-Ning Pan, Danfeng Wang, Jialong Jie, Ganglong Cui, Shuyi Yan, Hongmei Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuo WangCollege of Chemistry, Beijing Normal University, Beijing 100875, China.
Qian ZhouCollege of Chemistry, Beijing Normal University, Beijing 100875, China.
Guang-Ning PanCollege of Chemistry, Beijing Normal University, Beijing 100875, China.
Danfeng WangCollege of Chemistry, Beijing Normal University, Beijing 100875, China.
Jialong JieCollege of Chemistry, Beijing Normal University, Beijing 100875, China.
Ganglong CuiCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID https://orcid.org/0000-0002-9752-1659
Shuyi YanCollege of Chemistry, Beijing Normal University, Beijing 100875, China.
Hongmei SuCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID https://orcid.org/0000-0001-7384-6523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Phenylethynyl-4-thiouridine (5ph-4TU), featuring both π-conjugated phenylethynyl and carbonyl-sulfur substitutions, overcomes the UVA absorption limitations of conventional thio-nucleosides by extending absorption into visible and potentially longer-wavelength regions under single or two photon excitationan essential advancement for enhancing nucleosides' photoactivity toward deep-tissue cancer photodynamic therapy (PDT). However, the ultrafast excited-state dynamics and synergistic effects of these dual modifications remain unexplored, despite their critical role in generating unique excited-state characters inaccessible for canonical nucleosides. Here, we employ ultrafast spectroscopy combined with QM-(MS-CASPT2//CASSCF)/MM calculations to map out the unusual excited-state pathways of 5ph-4TU. We reveal that the C5-phenylethynyl group can effectively suppress C5C6 bond twisting to incur a high barrier of 0.8 eV from the S

Indexed as

Conical intersectionElectronic StructureExcited state dynamicsNucleobasePhotoreactivity

Identifiers

PMID42358716
PMCPMC13292003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.