Evidence map›Paper›PMID 42358697›Full record

ArticleJACS Au2026

Switchable Reactivity of Hydrazonoyl Halides: Enabling the Discovery of Potent Hypoxia-Inducible Factor Inhibitors.

Xiaochen Tian, Hongli Wu, Yaoyu Shi, Xiaonan Cui, Ruochen Pang, Boqi Zhang, Rongrong Zhou, Ling Lu, Yun-Fang Yang, Yang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaochen TianMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Hongli WuState Key Laboratory of Advanced Separation Membrane Materials, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.
Yaoyu ShiMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Xiaonan CuiMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Ruochen PangMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Boqi ZhangMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Rongrong ZhouState Key Laboratory of Advanced Separation Membrane Materials, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.
Ling LuMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
Yun-Fang YangState Key Laboratory of Advanced Separation Membrane Materials, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.
Yang WangMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.ORCID https://orcid.org/0000-0003-2054-9394

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A substituent-regulated divergent cycloaddition reaction between hydrazonoyl halides and 2-aminochalcones has been developed. In this study, substituents effectively reversed the intrinsic reactivity of hydrazonoyl halides, marking the first instance where hydrazonoyl halides can function as C1 synthonswith the azomethine carbon displaying unprecedented nucleophilic reactivity, a property that deviates from the established paradigms of hydrazonoyl halide chemistry. The reaction mechanism underlying this methodology was verified via density functional theory calculations. Moreover, biological activity evaluations demonstrated that the synthesized indolines suppress hypoxia-inducible factor activity both

Indexed as

benzotriazepinedivergent reactionhydrazonoyl halidehypoxia-induced factorindoline

Identifiers

PMID42358697
PMCPMC13291954

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.