ReviewAesthetic surgery journal. Open forum2026
Helium Plasma Radiofrequency for Aesthetic Subdermal Treatment: A Systematic Review and Meta-Analysis.
Review in Aesthetic surgery journal. Open forum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helium plasma radiofrequency (RF) technology (Renuvion, Apyx Medical, Clearwater, FL) has emerged as a minimally invasive option for treating skin laxity, either as a standalone procedure or as an adjunct to liposuction. While clinical adoption has expanded rapidly, the literature remains heterogeneous, with variable study designs and outcomes. To comprehensively evaluate the safety and performance of helium plasma RF for aesthetic subdermal applications through systematic review and meta-analysis. A systematic search was performed from initial device clearance through May 2025, following PRISMA guidelines. Eligible studies included randomized controlled trials, prospective cohorts, retrospective reviews, and case series with ≥10 patients undergoing aesthetic subdermal treatment with helium plasma RF. Safety outcomes were tabulated and weighted incidence rates calculated. Random-effects meta-analyses were performed to generate pooled estimates for performance endpoints, including patient satisfaction, investigator global aesthetic improvement scale (GAIS), patient GAIS, and independent photographic review scores. Thirty-four studies across 33 publications encompassing 3508 patients were included. Pooled complication rates were 5% for helium plasma RF-only, 8% for helium plasma RF + liposuction, and 15% for combination procedures involving multimodal excisional surgery; differences between groups were not statistically significant (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.