ArticleFrontiers in cardiovascular medicine2026
Sex-specific differences in the prognostic value of ischemic pre-hospital ECGs.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Background: The identification of myocardial infarction (MI) requiring target lesion revascularization (TLR) in women remains challenging. Objective: To investigate sex-specific differences in value of preclinical ischemic ECGs for identification of MI requiring TLR and mortality. Methods: Patients with suspected MI (ST-elevation MI [STEMI] excluded) and preclinical ECGs (1/2014-11/2021), who underwent coronary angiography (CA) were identified. Ischemic ECG was defined as composite of: ST-depression/elevation (not STEMI), T-wave inversion, left bundle branch block or ventricular fibrillation/tachycardia. The primary endpoint was MI requiring TLR, secondary endpoints were 30-day and 5-year all-cause mortality. The association between an ischemic ECG and endpoints was tested using logistic regression. Multivariable analysis was adjusted for age, previous percutaneous coronary intervention or MI, hypertension, diabetes, severely reduced left ventricular ejection fraction, renal failure and time to CA. Results: 1,963 patients were included in the study (age 72 [IQR 61-80], 654 [33.3%] females). Men presented with an ischemic ECG (63 vs. 52%; Conclusion: An ischemic prehospital ECG predicts MI requiring TLR in female patients and identifies high-risk patients for mortality in both sexes.
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