ArticleFrontiers in aging neuroscience2026
Evaluation of the association between MREPT-derived conductivity and IVIM-derived ISF-related metrics in the brains of patients with cognitive impairments.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Alterations in the ionic microenvironment and interstitial fluid (ISF) dynamics are increasingly recognized as early pathological events in Alzheimer's disease (AD). However, the Purpose: This study aimed to investigate the relationship between magnetic resonance electrical properties tomography (MREPT)-derived high-frequency conductivity (HFC) and intravoxel incoherent motion (IVIM)-derived ISF-related metrics in patients with cognitive impairments across the cognitively normal to AD spectrum. Methods: A total of 161 participants (26 cognitively normal (CN), 78 with amnestic mild cognitive impairment (MCI), and 57 with AD) underwent 3.0 T MRI. HFC maps were reconstructed using phase-based MREPT. ISF-related diffusion (D Results: Along the disease progression from CN to AD, D Conclusion: The region-specific associations observed between MREPT-derived HFC and IVIM-derived ISF-related metrics in select AD-vulnerable regions, particularly the independent D
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