Evidence map›Paper›PMID 42358585›Full record

ArticleRegenerative biomaterials2026

Vitronectin-GM-CSF fusion protein hydrogel with a recruitment-anchoring-activation strategy accelerates vascularized tissue regeneration.

Jiake Zhang, Yuhan Xia, Xueliang Peng, Wenjing Li, Yuzhen Zhao, Fulin Chen, Zhuoyue Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiake ZhangProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Faculty of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an 710069, Shaanxi Province, China.
Yuhan XiaProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Faculty of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an 710069, Shaanxi Province, China.
Xueliang PengProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Faculty of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an 710069, Shaanxi Province, China.
Wenjing LiProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Faculty of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an 710069, Shaanxi Province, China.
Yuzhen ZhaoProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Faculty of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an 710069, Shaanxi Province, China.
Fulin ChenProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Faculty of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an 710069, Shaanxi Province, China.
Zhuoyue ChenProvincial Key Laboratory of Biotechnology of Shaanxi, Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Faculty of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an 710069, Shaanxi Province, China.ORCID https://orcid.org/0000-0003-0590-2401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The process of tissue injury repair involves the synergistic effects of angiogenesis and immune regulation, yet a single molecule rarely can regulate both processes. To address this, we designed a fusion protein, VGC, by integrating the potent chemotactic property of granulocyte-macrophage colony-stimulating factor (GM-CSF) with the cell-anchoring domain of vitronectin (VTN). This design yielded an integrated system capable of recruiting, anchoring and activating repair cells. The VGC, connecting VTN and GM-CSF via linker peptides (GGGGSGGGGS), was successfully produced by microbial fermentation and loaded into temperature-sensitive Pluronic F127 hydrogel (F127) for controlled release.

Indexed as

angiogenesisimmune modulationtissue regenerationVGC hydrogelvitronectin-GM-CSF fusion protein

Identifiers

PMID42358585
PMCPMC13291906

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.