ArticleFoot & ankle orthopaedics2026
Association Between GLP-1RAs and Postoperative Complications Following Operative Ankle Fracture Fixation: A Retrospective Cohort Study.
Article in Foot & ankle orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Ankle fractures occur at an estimated rate of 4.22 per 10 000 person-years, occurring most frequently within the 21- to 30-year-old demographic. This retrospective cohort study used the TriNetX research network to evaluate the association between perioperative glucagon-like peptide-1 receptor agonist (GLP-1RA) use and postoperative complications following operative ankle fixation. Methods: Adults were stratified by GLP-1RA exposure (n = 1199 for the 3-month cohort and n = 1397 for both the 6- and 12-month cohorts). These cohorts were balanced via 1:1 propensity score matching for age, race, sex, wound healing risk factors, and diabetes; matching was attempted for body mass index (BMI) and glycated hemoglobin (HbA Results: Results demonstrated that GLP-1RA therapy was significantly associated with increased risk of hardware failure, beginning at 3 months (log rank test [LRT] χ Conclusion: These findings suggest that perioperative GLP-1RA use is associated with increased rates of hardware failure and nonunion/malunion, identifying a risk profile localized to osseous integrity. No association was found with postoperative infection, and a neutral significance was established for soft tissue complications. Interpreted in the context of residual imbalance in BMI and HbA Level of Evidence: Level III, retrospective cohort study.
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