ArticleAlzheimer's & dementia (New York, N. Y.)
Person-centered intervention response in primary progressive aphasia: A secondary analysis of the Communication Bridge-2 randomized clinical trial.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Care Partner Perceptions of Conversation Difficulties, Strategy Use, and Psychosocial Impacts in Primary Progressive Aphasia: A Descriptive Study Using the PCI-DAT.Brain sciences · 2026Article
- Person-centered intervention response in primary progressive aphasia: A secondary analysis of the Communication Bridge-2 randomized clinical trial.Alzheimer's & dementia (New York, N. Y.)Article
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8 authors.
Funding
Abstract
introductionPerson-centered outcomes that capture clinically meaningful change are essential to non-pharmacological intervention research for Alzheimer's disease and related dementias. Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by progressive language impairment. The Communication Bridge-2 (CB2) randomized controlled trial previously demonstrated the efficacy of a personalized, participation-focused speech-language intervention on Goal Attainment Scaling (GAS), a person-centered communication participation outcome. This secondary responder analysis characterized meaningful participant- and goal-level response following intervention and at 12 months after enrollment to inform clinical translation and future appropriate use criteria.
methodsFifty participants with mild to moderate PPA in the CB2 experimental arm, each with three individualized communication participation goals (
resultsAll participants met responder criteria at one or more evaluation time points. At 12 months, 79% of goals met responder criteria, and 60% of participants met responder criteria across all three goals. More than half of the goals (51.3%) met responder criteria at all three evaluation time points. Meaningful response was observed across PPA subtypes, baseline severity levels, and diverse goal characteristics. Exploratory patterns suggested higher 12-month responder rates for goals targeting speech, familiar communication partners, and familiar communication contexts. DISCUSSION: This secondary responder analysis demonstrates that a person-centered, participation-focused speech-language intervention was associated with meaningful goal-level improvement or maintenance across a heterogeneous PPA population, with many responses sustained over 12 months. These findings support the value of GAS as a pragmatic, person-centered outcome for capturing meaningful response in progressive neurodegenerative disease and provide translational evidence to inform future appropriate use criteria and individualized dementia care.
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