Evidence map›Paper›PMID 42358385›Full record

ArticleACS sustainable chemistry & engineering2026

Engineering and Application of a Thermostable MHETase for PET Depolymerization.

Natasha P Murphy, Japheth E Gado, Tabea Neumann, Pablo Perez-Garcia, Evan Komp, Luisana Avilan, Irimpan I Mathews, Elizabeth L Bell, Brenna Norton-Baker, Matilda Clark and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS sustainable chemistry & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Natasha P MurphyRenewable Resources and Enabling Sciences Center, National Laboratory of the Rockies, Golden, Colorado 80401, United States.ORCID https://orcid.org/0000-0001-6915-9990
Japheth E GadoRenewable Resources and Enabling Sciences Center, National Laboratory of the Rockies, Golden, Colorado 80401, United States.
Tabea NeumannDepartment of Microbiology and Biotechnology, University of Hamburg, Hamburg 22609, Germany.
Pablo Perez-GarciaDepartment of Microbiology and Biotechnology, University of Hamburg, Hamburg 22609, Germany.
Evan KompRenewable Resources and Enabling Sciences Center, National Laboratory of the Rockies, Golden, Colorado 80401, United States.
Luisana AvilanCentre for Enzyme Innovation, School of the Environment and Life Sciences, University of Portsmouth, Portsmouth PO1 2DY, U.K.
Irimpan I MathewsSLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Menlo Park, California 94025, United States.ORCID https://orcid.org/0000-0001-6254-3519
Elizabeth L BellRenewable Resources and Enabling Sciences Center, National Laboratory of the Rockies, Golden, Colorado 80401, United States.ORCID https://orcid.org/0000-0002-8247-743X
Brenna Norton-BakerRenewable Resources and Enabling Sciences Center, National Laboratory of the Rockies, Golden, Colorado 80401, United States.
Matilda ClarkCentre for Enzyme Innovation, School of the Environment and Life Sciences, University of Portsmouth, Portsmouth PO1 2DY, U.K.
Rebecca R GarciaRenewable Resources and Enabling Sciences Center, National Laboratory of the Rockies, Golden, Colorado 80401, United States.
Hannah M AltRenewable Resources and Enabling Sciences Center, National Laboratory of the Rockies, Golden, Colorado 80401, United States.
Ritimukta SarangiBOTTLE Consortium, Golden, Colorado 80401, United States.ORCID https://orcid.org/0000-0002-2764-2279
Andrew R PickfordCentre for Enzyme Innovation, School of the Environment and Life Sciences, University of Portsmouth, Portsmouth PO1 2DY, U.K.ORCID https://orcid.org/0000-0002-7237-0030
Wolfgang R StreitDepartment of Microbiology and Biotechnology, University of Hamburg, Hamburg 22609, Germany.ORCID https://orcid.org/0000-0001-7617-7396
John E McGeehanRenewable Resources and Enabling Sciences Center, National Laboratory of the Rockies, Golden, Colorado 80401, United States.
Nicholas P GauthierDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Gregg T BeckhamRenewable Resources and Enabling Sciences Center, National Laboratory of the Rockies, Golden, Colorado 80401, United States.ORCID https://orcid.org/0000-0002-3480-212X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enzymatic hydrolysis of poly-(ethylene terephthalate) (PET) releases mono-(2-hydroxyethyl) terephthalate (MHET) as a major product, the accumulation of which can prolong reactor residence times and complicate downstream monomer separations. The use of a MHETase enzyme can enable MHET hydrolysis to the monomers, terephthalic acid and ethylene glycol, but industrial PETases typically operate at thermophilic temperatures and the well-known MHETase from

Indexed as

EnzymesHigh-throughput assayInterfacial biocatalysisPolymersProtein engineering

Identifiers

PMID42358385
PMCPMC13292399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.