ArticleAdvanced nanobiomed research2026
Lysyl Oxidase Reduces Neutrophil Extravasation in Response to
Article in Advanced nanobiomed research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neutrophils are crucial players in the fight against infections. Unfortunately, dysregulated neutrophil function contributes to the pathogenesis of diseases, including cancer, fibrosis, and atherosclerosis, that leave those afflicted vulnerable to severe infections. Many of these diseases are accompanied by differential lysyl oxidase (LOX) activity. The LOX enzyme crosslinks collagen and elastin, two highly expressed proteins in the extracellular matrix (ECM), altering the ECM's mechanical properties. While it is known ECM mechanical properties regulate neutrophil function, the role of LOX crosslinking of collagen on the neutrophil response is unclear. This study uses a microfluidic "infection-on-a-chip". This device consists of a model blood vessel endothelium embedded in an ECM mimic to investigate the how LOX crosslinking of collagen affects neutrophil function in response to infection. Interestingly, LOX-crosslinking of collagen deceases neutrophil extravasation through an endothelium in response to
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