Evidence map›Paper›PMID 42358374›Full record

ArticleFrontiers in pharmacology2026

Comparative neuroprotective and exercise capacity effects of prophylactic intermittent fasting and probiotics in sleep-deprived rats: insights into anti-inflammatory marker modulation and

Eman I Elgizawy, Reda A A Abo-Elsoud, Anwar M Shaban, Hala F M Kamel, Hiba S Al-Amodi, Shimaa Abdelsattar, Rana T Hikal, Shaimaa M Hassan

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Eman I ElgizawyMedical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.
Reda A A Abo-ElsoudMedical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.
Anwar M ShabanMedical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.
Hala F M KamelMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hiba S Al-AmodiBiochemistry Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Shimaa AbdelsattarClinical Biochemistry and Molecular Diagnostics Department, National Liver Institute, Menoufia University, Shebin El Kom, Menoufia, Egypt.
Rana T HikalMedical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.
Shaimaa M HassanHistology and Cell Biology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prophylactic probiotics and intermittent fasting (IF) substantially modulate the neuropsychological functions and exercise capacity in rats subjected to sleep deprivation (SD). A comparative study was conducted to analyze the effects of probiotics and IF on SD-induced neuropsychological disturbances and compromised muscle endurance. Methods: Forty albino Wistar rats were randomly assigned to four groups. The NSD group was maintained on a standard chow diet for 12 weeks. The SD group followed an SD regimen for 72 h per week over 8 weeks, starting from the fifth week. The SDP group received probiotics at a dose of colony-forming units (CFUs)/100 g/day for 4 weeks prior to SD, followed by 8 weeks of concurrent probiotic administration with SD. The SDIF group underwent an alternate-day fasting regimen for 4 weeks before SD, followed by 8 weeks of simultaneous SD combined with IF. Neuropsychological functions and exercise capacity were tested, and then the brains were carefully dissected, sectioned, and processed for hematoxylin and eosin, cresyl violet, and immunohistochemical staining. Results: Inflammatory markers, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and hippocampal expression of the circadian locomotor output cycles kaput ( Conclusion: These findings indicate that prophylactic probiotics decrease cognitive disruption and impaired muscle endurance caused by SD through

Indexed as

cleaved caspase-3CLOCK geneglial fibrillary acidic proteinhippocampusintermittent fastingneuroinflammationprobioticssleep deprivation

Identifiers

PMID42358374
PMCPMC13290755

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