Evidence map›Paper›PMID 42358308›Full record

ArticleFrontiers in nutrition2026

Association between vitamin A and D levels and the risk of type 1 diabetes mellitus in children.

Shuhan Rao, Tiewei Li, Zhaoli Yan, Xiaojuan Li, Wan Sun, Shengnan Li, Ligong Hou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuhan Rao *Department of Clinical Laboratory, Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Tiewei Li *Department of Clinical Laboratory, Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Zhaoli YanDepartment of Endocrinology, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Medical University, Hohhot, China.
Xiaojuan LiDepartment of Clinical Laboratory, Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Wan SunDepartment of Clinical Laboratory, Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Shengnan LiDepartment of Endocrinology, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Medical University, Hohhot, China.
Ligong HouHenan International Joint Laboratory of Prevention and Treatment of Pediatric Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamin A (VA) and vitamin D (VD) play crucial roles in immune regulation, yet their status in pediatric type 1 diabetes mellitus (T1DM) remains underexplored. This study aims to investigate the association between VA and VD levels and T1DM in children, providing a scientific basis for potential nutritional intervention strategies. Methods: This retrospective observational study was conducted at the Children's Hospital Affiliated to Zhengzhou University. The study enrolled 31 children diagnosed with T1DM who underwent vitamin testing between January 2022 and October 2025. A control group of 31 children who received health examinations and VA assessments during the same period was included for comparison. Clinical and laboratory data were extracted from the hospital's electronic medical records system. Results: The levels of serum VA and VD in children with T1DM were significantly lower than those in the control group, and the deficiency rate was correspondingly increased. Correlation analysis showed that the levels of VA ( Conclusion: Serum levels of VA and VD are significantly associated with fasting blood glucose in children and show an independent association with T1DM. These findings suggest that maintaining appropriate VA and VD status may have some significance in the clinical management of T1DM in children, but they still need to be verified by rigorous longitudinal and interventional studies.

Indexed as

childrenrelevancetype 1 diabetes mellitusvitamin Avitamin D

Identifiers

PMID42358308
PMCPMC13290505

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.