Evidence map›Paper›PMID 42358210›Full record

ArticlePhysiological reports2026

Weaning stress induced alterations to the hypothalamic-pituitary-thyroid and -adrenal axes in swine.

Isabel B Walpole, Alyssa A Smith, Kaylyn G Rudy, Dayeon Jeon, J Scott Radcliffe, J Alex Pasternak

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In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Isabel B WalpoleDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.
Alyssa A SmithDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.
Kaylyn G RudyDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.
Dayeon JeonDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.
J Scott RadcliffeDepartment of Animal and Food Sciences, University of Kentucky, Lexington, Kentucky, USA.
J Alex PasternakDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0001-8596-3057

Funding

USDA | National Institute of Food and Agriculture (NIFA) 2023-67015-39338
6 · The paper itself

Abstract

Combined modulation of the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-adrenal (HPA) axes is known to play a critical role in maintaining physiological stability in response to stress. In this study, stress induced modulation of these axes was examined using 20 pigs/treatment either weaned (WN), weaned with feed/water restriction 9 h (FR), transported 9 h (TRANS), or remaining with sow (SOS) and euthanized at 32 or 56 h post-weaning. Serum cortisol, thyroxine (T4), and triiodothyronine (T3) were measured before weaning and after 24, 32, and 56 h with no difference in cortisol concentrations among treatments at any timepoint. However, both T3 and T4 decreased post-weaning in FR, TRANS, and WN compared to SOS. Expression of 23 genes of interest was evaluated across the hypothalamus, pituitary, thyroid, and adrenal glands of TRANS and SOS pigs at 56 h to understand the underlying mechanism. TSHB, DIO3, and POMC expression was decreased in the pituitary while DIO3 in the thyroid was increased, with upregulation in MC2R also observed. Collectively, these results suggest acute stressors in swine can induce type I allostasis within the HPT axis and modulate sensitivity within the HPA.

Indexed as

Hypothalamo-Hypophyseal SystemPituitary-Adrenal SystemStress, PhysiologicalThyroid GlandWeaningAnimalsFemaleHydrocortisoneIodide PeroxidaseSwineThyroxineTriiodothyronineHydrocortisoneIodide PeroxidaseThyroxineTriiodothyronineallostasisnon‐thyroidal illness syndromestressswinethyroid

Identifiers

PMID42358210
PMCPMC13305662

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.