ArticlePhysiological reports2026
Low-intensity ultrasound induces angiogenesis by activating endothelial integrin signaling in male mice.
Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Peripheral arterial disease is a medical condition caused by blockages of arteries that provide blood flow to the arms or legs. Pulsed ultrasound (PUS) has been widely used for some therapies such as bone fracture healing. We hypothesized that PUS also affects angiogenesis for ischemia therapy. This study was performed to elucidate the mechanism of PUS therapeutic angiogenesis and evaluate PUS efficacy. Hindlimb ischemic model mice were applied PUS irradiation for 20 min/day for 2 weeks. In consequence, the blood flow rates in hindlimb ischemic model mice treated with PUS improved compared with those in untreated mice. Then we performed a tube formation assay using a human umbilical vein endothelial cell (HUVEC) under conditions of PUS exposure. To elucidate the signal transduction mechanism initiated by PUS stimulation in HUVECs, we evaluated phosphorylation profiles with antibody array analysis. PUS irradiation enhanced tube formation in HUVECs and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 through the integrin pathway. Moreover, the blood flow recovery in hindlimb ischemic model mice treated with PUS was completely inhibited in mice administered an anti-integrin blocking antibody. These findings suggested that PUS demonstrated angiogenic effects through the integrin pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.