Evidence map›Paper›PMID 42358190›Full record

ArticleTransboundary and emerging diseases2026

Foot-and-Mouth Disease Virus Persistence Divergence Within Serotypes and Vaccine Doses in Vaccinated Cattle.

Zhihui Zhang, Sumin Wei, Zhidong Teng, Shuanghui Yin, Suyu Mu, Jinwei Huang, Shuang Wang, Guoliang Huang, Yaozhong Ding, Yun Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhihui ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.
Sumin WeiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.
Zhidong TengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.
Shuanghui YinState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.ORCID https://orcid.org/0000-0001-7276-9140
Suyu MuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.
Jinwei HuangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.
Shuang WangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.ORCID https://orcid.org/0000-0002-8729-1626
Guoliang HuangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.
Yaozhong DingState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.
Yun ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.
Yijing LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China, neau.edu.cn.
Shiqi SunState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.
Huichen GuoState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.ORCID https://orcid.org/0000-0003-0539-497X

Funding

Key Research and Development Program of Ningxia 2024BBF02017National Key Research and Development Program of China 2021YFD1800303National Natural Science Foundation of China 32301127National Natural Science Foundation of China 32473012Science and Technology Program of Gansu Province 24CXNA030Science and Technology Program of Gansu Province 25JRRA1086Science and Technology Program of Gansu Province 25JRRA1089Science and Technology Program of Gansu Province 25YFNA014
6 · The paper itself

Abstract

Foot-and-mouth disease virus (FMDV) persistence in ruminants constitutes the potential risk of disease transmission. While vaccination effectively protects animals against clinical disease, more than 50% of vaccinated cattle can still develop persistent infection. Investigating the potential factors that influence the establishment of FMDV persistence in vaccinated cattle is critical for improving control and eradication strategies in epidemic regions. Here, cattle vaccinated with different doses of serotype O and serotype A vaccines were experimentally challenged with the homologous virus. The overall incidence of the carrier state was 22.5%. Although higher levels and prolonged detection of viral RNA in oesophagal-pharyngeal fluids (OPFs) were observed in the two higher-dose groups of both serotypes, neither viral serotype nor vaccine dose significantly influenced the final carrier incidence. Notably, most carriers showed a slower rise in antigen-specific and neutralizing antibody (NAb) titers postchallenge, resulting in significantly lower antibody titers during the early infection stage, irrespective of the viral serotypes or vaccine doses. Viral genomes and particles were predominantly localized within nasopharyngeal tissues, including the nasopharynx, soft palate, and adjacent lymph nodes and tonsils. In addition, carriers exhibited an increased number of germinal centers in the lymph nodes and tonsils. These findings provide novel insights into the immunological features associated with FMDV persistence in vaccinated cattle and offer a theoretical foundation for optimizing vaccine design and developing targeted immune intervention strategies.

Indexed as

Cattle DiseasesFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusViral VaccinesAnimalsAntibodies, ViralCarrier StateCattleRNA, ViralSerogroupVaccinationAntibodies, ViralRNA, ViralViral Vaccines

Identifiers

PMID42358190
PMCPMC13305672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.