Evidence map›Paper›PMID 42358112›Full record

ArticleJACC. Advances2026

Small Mitral Valve Orifice Area in Mitral Valve Transcatheter Edge-to-Edge Repair: The REPAIR Study.

Philipp von Stein, Jennifer von Stein, Florian Schindhelm, Felix Rudolph, Paula Sagmeister, Jean Marc Haurand, Jannik Jobst, Matthias Gröger, Lukas Stolz, Carl Schulz and 28 more

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In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Philipp von SteinDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany; Cardiovascular Research Foundation, New York, New York, USA; Center for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany. Electronic address: philipp.von-stein@uk-koeln.de.
Jennifer von SteinDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany; Cardiovascular Research Foundation, New York, New York, USA; Center for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany.
Florian SchindhelmDepartment of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, University of Duisburg Essen, Essen, Germany.
Felix RudolphClinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany; Herz- und Diabeteszentrum Nordrhein-Westfalen, Med. Fakultät OWL (Universität Bielefeld), Bad Oeynhausen, Germany.
Paula SagmeisterDepartment of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Science, Leipzig, Germany.
Jean Marc HaurandCenter for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany; Department of Cardiology, Pulmonology and Vascular Medicine, University Hospital Düsseldorf, Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Jannik JobstDepartment of Cardiology and Angiology, Justus-Liebig-University Giessen, Giessen, Germany.
Matthias GrögerDepartment of Internal Medicine II, Ulm University Heart Center, Ulm, Germany.
Lukas StolzMedizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität München, Munich, Germany; Munich Heart Alliance, Partner Site German Center for Cardiovascular Disease (DZHK), Munich, Germany.
Carl SchulzDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christoph Alexander MuesMedical Clinic I, Department of Cardiology, St. Johannes Hospital, Dortmund, Germany.
Donika MustafaDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany; Center for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany.
Isabel A HoerbrandDepartment of Internal Medicine III, Division of Cardiology, University Hospital Heidelberg, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.
Atsushi SugiuraCenter for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany; Department of Internal Medicine II, Heart Center Bonn, University Hospital Bonn, Bonn, Germany.
Charlotte WolffDepartment of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Science, Leipzig, Germany.
Philipp LurzDepartment of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Philipp JahnDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany; Center for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany.
Guido AscioneCardiovascular Research Foundation, New York, New York, USA.
Henning GuthoffDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany; Center for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany.
Stephan BaldusDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany; Center for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany.
Wolfgang RottbauerDepartment of Internal Medicine II, Ulm University Heart Center, Ulm, Germany.
Muhammed GerçekClinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany; Herz- und Diabeteszentrum Nordrhein-Westfalen, Med. Fakultät OWL (Universität Bielefeld), Bad Oeynhausen, Germany.
Roman PfisterDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany; Center for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany.
Tienush RassafDepartment of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, University of Duisburg Essen, Essen, Germany.
Marcel WeberCenter for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany; Department of Internal Medicine II, Heart Center Bonn, University Hospital Bonn, Bonn, Germany.
Mathias KonstandinDepartment of Internal Medicine III, Division of Cardiology, University Hospital Heidelberg, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.
Helge MöllmannMedical Clinic I, Department of Cardiology, St. Johannes Hospital, Dortmund, Germany.
Niklas SchoferDepartment of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jörg HausleiterMedizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität München, Munich, Germany; Munich Heart Alliance, Partner Site German Center for Cardiovascular Disease (DZHK), Munich, Germany.
Mirjam KesslerDepartment of Internal Medicine II, Ulm University Heart Center, Ulm, Germany.
Bernhard UnsöldDepartment of Cardiology and Angiology, Justus-Liebig-University Giessen, Giessen, Germany.
Patrick HornCenter for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany; Department of Cardiology, Pulmonology and Vascular Medicine, University Hospital Düsseldorf, Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Tobias KisterDepartment of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Science, Leipzig, Germany.
Volker RudolphClinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany; Herz- und Diabeteszentrum Nordrhein-Westfalen, Med. Fakultät OWL (Universität Bielefeld), Bad Oeynhausen, Germany.
Amir Abbas MahabadiDepartment of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, University of Duisburg Essen, Essen, Germany.
Juan F GranadaCardiovascular Research Foundation, New York, New York, USA.
Victor MauriDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany; Center for Cardiovascular Medicine ABCD, Aachen - Bonn - Cologne-Düsseldorf, Germany. Electronic address: https://twitter.com/VictorMauriMD.
REPAIR Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMitral valve transcatheter edge-to-edge repair (M-TEER) is an established therapy for patients with mitral regurgitation (MR) at high surgical risk. By reducing the mitral valve orifice area (MVOA), M-TEER may increase the risk of iatrogenic mitral stenosis. Data for PASCAL M-TEER according to 3-dimensional (3D)-MVOA remain limited.

objectivesThe objective of the study was to compare procedural, echocardiographic, and clinical outcomes after PASCAL M-TEER according to baseline 3D-MVOA.

methodsPatients with available baseline 3D-MVOA from the investigator-initiated multicenter REPAIR registry were stratified by 3D-MVOA (<4 vs ≥4 cm

resultsAmong 1,189 patients (mean age 78 ± 9 years, 44% female, 86% NYHA functional class III/IV, mean 3D-MVOA 4.9 ± 1.6 cm

conclusionsAlmost one-third of patients with available measurements had baseline 3D-MVOA <4 cm

Indexed as

3-dimensionalmitral regurgitationMRM-TEERMVOAPASCAL

Identifiers

PMID42358112
PMCPMC13531619

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