Evidence map›Paper›PMID 42357956›Full record

ArticleTurkish journal of haematology : official journal of Turkish Society of Haematology2026

Increased Mast Cell Numbers in Bone Marrow of Patients with Myeloproliferative Neoplasms and Pruritus

Maud Hermans, Peter Westerweel, Thierry van den Bosch, Willem Dik, King Lam, Sanne Van Den Meerendonk, Francien Nederveen, Vincent van der Velden, Peter te Boekhorst

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In one paragraph

Article in Turkish journal of haematology : official journal of Turkish Society of Haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maud HermansErasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, Division of Allergy and Clinical Immunology, Rotterdam, the NetherlandsORCID 0009-0002-9735-1423
Peter WesterweelAlbert Schweitzer Hospital, Department of Internal Medicine, Division of Hematology, Dordrecht, the NetherlandsORCID 0000-0002-0746-7039
Thierry van den BoschErasmus MC, Department of Pathology, Rotterdam, the NetherlandsORCID 0000-0002-7223-4565
Willem DikErasmus MC, Department of Immunology, Laboratory of Medical Immunology, Rotterdam, the NetherlandsORCID 0000-0001-5235-3156
King LamErasmus MC, Department of Pathology, Rotterdam, the NetherlandsORCID 0000-0003-3903-1085
Sanne Van Den MeerendonkErasmus MC, Department of Immunology, Laboratory of Medical Immunology, Rotterdam, the NetherlandsORCID 0009-0000-4713-3896
Francien NederveenPAL Dordrecht, Dordrecht, the NetherlandsORCID 0000-0002-0805-7023
Vincent van der VeldenErasmus MC, Department of Immunology, Laboratory of Medical Immunology, Rotterdam, the NetherlandsORCID 0000-0001-9457-3763
Peter te BoekhorstErasmus MC Cancer Institute, Department of Hematology, Rotterdam, the NetherlandsORCID 0000-0002-3566-5016

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pruritus may be a debilitating symptom in cases of myeloproliferative neoplasm (MPN). Since mast cells (MCs) play a pivotal role, we hypothesized that bone marrow (BM) MCs contribute to the occurrence of pruritus. In this exploratory study, untreated MPN patients were included. BM aspirate/biopsy/blood samples and responses to the MPN-Symptom Assessment Form were obtained. Thirty-two patients were included (essential thrombocythemia, n=19; polycythemia vera, n=7; primary myelofibrosis, n=6). Eleven had clinically significant pruritus (35%). The absolute MC count and proportion per total nucleated BM cells were significantly higher in patients with pruritus compared to those without (mean of 25.5 vs. 58.1 MCs/mm

Indexed as

Bone MarrowBone Marrow CellsMast CellsMyeloproliferative DisordersPruritusAdultAgedAged, 80 and overCell CountFemaleHumansMaleMiddle AgedMast cellsMyeloproliferative neoplasmsPruritus

Identifiers

PMID42357956
PMCPMC13540401

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.