ArticleJournal of the American Chemical Society2026
A Vakognavine-Type Diterpenoid Alkaloid as FoxO1 Inhibitors against Rheumatoid Arthritis.
Rongrong Zhang, Xuechun Yu, Siyuan Du, Ruidan Hu, Ruian Chen, Lin An, Zhongqiu Liu, Caiyan Wang
Abstract read
In one paragraphArticle in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Rongrong ZhangState Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID 0000-0002-8876-1618 Xuechun YuState Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Siyuan DuState Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Ruidan HuState Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Ruian ChenState Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Lin AnState Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Zhongqiu LiuState Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID 0000-0001-6986-9677 Caiyan WangState Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID 0000-0002-8605-2340 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Rheumatoid arthritis is a systemic autoimmune disorder with a markedly unmet clinical need for highly effective and well-tolerated therapeutic agents with minimal toxicity. Herein, 15 C20-diterpenoid alkaloids, including nine novel compounds, delphyuanines A-I (
Indexed as
AlkaloidsArthritis, RheumatoidDiterpenesForkhead Box Protein O1AnimalsArthritis, ExperimentalMacrophagesMiceNF-kappa BNitric OxideRatsAlkaloidsDiterpenesForkhead Box Protein O1Foxo1 protein, ratNF-kappa BNitric Oxide
Identifiers
PMID42357943
PMCPMC13353374
What OpenQuestion holds
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