Evidence map›Paper›PMID 42357695›Full record

ArticleViruses2026

Analysis of Epidemiological and Molecular Characteristics of Bocavirus in Guangzhou.

Yifan Pan, Pingting Zhu, Yiyun Chen, Jingjing Zhang, Yanhui Liu, Shuiping Hou, Anna Wang, Xinwei Wu, Pengzhe Qin, Lan Cao

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Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yifan PanSchool of Public Health, Guangzhou Medical University, Guangzhou 511436, China.ORCID 0009-0009-7834-8481
Pingting ZhuGuangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute), Guangzhou 510440, China.
Yiyun ChenGuangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute), Guangzhou 510440, China.
Jingjing ZhangGuangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute), Guangzhou 510440, China.
Yanhui LiuGuangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute), Guangzhou 510440, China.
Shuiping HouGuangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute), Guangzhou 510440, China.ORCID 0000-0003-4360-3322
Anna WangGuangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute), Guangzhou 510440, China.
Xinwei WuGuangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute), Guangzhou 510440, China.ORCID 0000-0002-5592-5153
Pengzhe QinGuangzhou Center for Disease Control and Prevention (Guangzhou Health Supervision Institute), Guangzhou 510440, China.
Lan CaoSchool of Public Health, Guangzhou Medical University, Guangzhou 511436, China.

Funding

Guangdong Provincial Key Laboratory of Geophysical High-resolution Imaging Technology 2023B1212010010Key Laboratory at the Nanning Center for Disease Control and Prevention NNCDC202502Key Project of Medicine Discipline of Guangzhou 2025-2027-11Research Support Project for Young and Middle-aged Talents in the Field of Infectious Disease Prevention and Control by the Chinese Preventive Medicine Association CPMA2024CRBFK
6 · The paper itself

Abstract

objectiveWe aimed to elucidate the epidemiological characteristics and co-infection status of HBoV in Guangzhou and to investigate the potential recombination events and alterations in antigenic properties among circulating HBoV strains.

methodsUtilizing respiratory specimens collected from patients at sentinel surveillance hospitals in Guangzhou between August 2023 and December 2025, multiplex pathogen detection was performed. We describe the temporal and demographic distribution of HBoV in Guangzhou and determine its co-infection patterns. Subsequent sequence analysis focused on identifying potential recombination events and characterizing antigenic properties.

resultsThe epidemiological features of HBoV in Guangzhou exhibited a primary epidemic peak around the autumn season, followed closely by a secondary peak. HBoV infection was predominantly observed in children under three years of age. Co-infections with rhinovirus and parainfluenza virus were common. Whole-genome sequencing yielded 15 complete HBoV genome sequences. Recombination analysis and verification suggested potential recombination events in two of these sequences. A comparative analysis of the antigenic characteristics of one identified recombinant strain, GZ-2024-20891, against its putative parental strains and domestic prevalent strains revealed potential alterations in its antigenic characteristic.

conclusionsBocavirus is highly prevalent among young children under 3 years of age, with a secondary peak following the main epidemic peaks around autumn in Guangzhou. Genetic recombination and potential antigenic alteration were detected in bocavirus.

Indexed as

Human bocavirusParvoviridae InfectionsChild, PreschoolChinaCoinfectionFemaleGenome, ViralHumansInfantMalePhylogenyPrevalenceRecombination, GeneticSeasonsWhole Genome Sequencingantigenic variationepidemiologygenetic recombinationhuman bocaviruswhole-genome sequencing

Identifiers

PMID42357695
PMCPMC13307671

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