ArticleViruses2026
Acquired HIV-1 Drug Resistance and Molecular Transmission Networks in Zhongwei, Ningxia, China.
Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
objectiveThis retrospective cross-sectional study aimed to characterize HIV-1 genotypes, assess drug resistance, and analyze molecular transmission networks in Zhongwei City to inform prevention strategies.
methodsPlasma samples were collected from antiretroviral therapy (ART)-treated patients (2007-2024) with viral load ≥ 200 copies/mL. HIV-1
results75 sequences were obtained. Males (84.00%), and heterosexual transmission (64.00%) predominated. CRF07_BC (46.67%) and CRF01_AE (38.67%) were the major subtypes; the overall ADR rate was 40.00%, mainly NNRTIs-associated (30.67% of all participants, including 16.00% single-class NNRTIs and 14.67% dual-class NRTIs-NNRTIs). Network inclusion rate was 40.00% of the 75 sequences; CRF07_BC showed higher betweenness centrality (
conclusionHIV-1 subtypes are diverse with high ADR. CRF07_BC may act as a transmission bridge, whereas CRF01_AE and CRF85_BC exhibit faster potential spread. Baseline DR testing and network-guided interventions are recommended.
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