Evidence map›Paper›PMID 42357651›Full record

ArticleViruses2026

Cathepsin C Restricts Influenza A Virus Replication and Is Associated with Suppression of the PI3K-AKT Signaling Pathway.

Yansheng Zhu, Lanlan Si, Zhongzhong Cao, Huiyang Song, Aiqing Yang, Xia Wang, Yifei Qiu, Chengming Gao, Gangqiao Zhou, Pengbo Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yansheng ZhuCollege of Life Sciences, Anhui Medical University, Hefei 230032, China.
Lanlan SiGraduate School, Guangzhou Medical University, Guangzhou 511436, China.
Zhongzhong CaoCollege of Life Sciences, Hebei University, Baoding 071002, China.
Huiyang SongAcademy of Military Medical Sciences, Beijing 100850, China.
Aiqing YangAcademy of Military Medical Sciences, Beijing 100850, China.
Xia WangAcademy of Military Medical Sciences, Beijing 100850, China.
Yifei QiuAcademy of Military Medical Sciences, Beijing 100850, China.
Chengming GaoAcademy of Military Medical Sciences, Beijing 100850, China.
Gangqiao ZhouCollege of Life Sciences, Anhui Medical University, Hefei 230032, China.
Pengbo CaoAcademy of Military Medical Sciences, Beijing 100850, China.

Funding

Guangzhou Laboratory No. GZNL2024A01001National Natural Science Foundation of China No.82172707National Natural Science Foundation of China No. 82573493
6 · The paper itself

Abstract

Cathepsin C (CTSC) is a major lysosomal cysteine protease characterized by its involvement in multiple essential pathological processes associated with various viral infections and pathogenesis, such as influenza virus and coronavirus. However, the antiviral spectrum of CTSC and the molecular mechanisms underlying its activity remain to be fully elucidated. In this study, we demonstrate that CTSC significantly inhibits the infection of influenza A virus (IAV) H1N1 both in vitro and in vivo. Mechanistically, the antiviral function of CTSC is associated with attenuation of the PI3K-AKT signaling pathway, thereby inducing cell apoptosis and reducing inflammation, which ultimately limits the virus's ability to hijack host resources. Taken together, our findings highlight the crucial role of CTSC in defense against H1N1 by targeting PI3K-AKT pathway and suggest a prospective antiviral target against the infection of H1N1.

Indexed as

Cathepsin CInfluenza A Virus, H1N1 SubtypePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionVirus ReplicationAnimalsApoptosisDogsHumansInfluenza A virusInfluenza, HumanMadin Darby Canine Kidney CellsMiceOrthomyxoviridae InfectionsCathepsin CPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktapoptosisCathepsin CH1N1inflammationPI3K-AKT pathway

Identifiers

PMID42357651
PMCPMC13307861

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.